Words similar to gr-responsive

Example sentences for: gr-responsive

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Like other steroid hormone receptors, GRs are phosphoproteins, and reversible phosphorylation of specific ser/thr residues on the GR or associated proteins has been implicated in the regulation of 1) hormone binding to the cytoplasmic GR-complex, 2) the translocation of the GR between the cytoplasm and the nucleus, 3) the binding of ligand activated GR to consensus GRE in the promoter regions of GR-responsive genes, and 4) the formation of an active transcriptional complex [ 1, 2, 5, 6, 7, 8, 28, 29, 30, 31].
In contrast, mobility gel-shift analysis revealed that treatment with ISIS 15534 produces a marked increase in the association of GR with GRE-containing DNA, and transient transfection studies employing a GR-responsive reporter plasmid revealed that the suppression of PP5 expression activates GR-dependent transcription in the absence of hormone [ 25].