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Example sentences for: golgins

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Since HEp-2 cells grown as a monolayer were observed to be more resistant to apoptosis compared with Jurkat cells, we used HEp-2 cells to investigate more precisely the relative kinetics of degradation for the native golgins during apoptosis.
It has been reported that some golgins are localized to the cytoplasmic face of Golgi membranes [ 16 ] . Functions of the golgins have been proposed in vesicular transport and in maintaining structural integrity of the Golgi complex [ 17 18 19 ] . The potential implication is that these Golgi proteins may have common biochemical characteristics that may make them targets of autoimmune responses in certain disease states.
Although we did not determine which golgins are substrates for specific caspases, further studies aimed at defining the caspases responsible for golgin cleavage, the cleavage sites, and the biological consequences of these cleavages should provide important insights into the possible role of some of the Golgi autoantigens in apoptosis.
These results suggested that there might be differences in the kinetics of degradation among the golgins, with golgin-95 and golgin-97 perhaps being more sensitive to proteolysis and being targeted very early during apoptosis.
In the present study, Jurkat cells were relatively sensitive to the treatment with STS such that the kinetics of degradation of different golgins relative to that of PARP could not be accurately differentiated.