Example sentences for: gmp

How can you use “gmp” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • They are constitutively permeable to water, and also function as regulated non-selective cation channels [ 10 ] when gated by intracellular cyclic GMP [ 11 12 ] . Even though only a small proportion of the AQP1 channels that are present in the membrane appear to be available for cGMP-activation of the ionic conductance (1/56,000), model-based calculations nonetheless suggest that this contribution could be meaningful in a physiological setting [ 13 ] . Unlike transporters which move substantial amounts of substrate by design, ion channels function to change membrane potential by the net movement of relatively tiny amounts of charge (~10 picomoles per cm 2membrane to generate a change of 100 mV) [ 14 ] , hence the low proportion of active AQP1 ion channels is consistent with a functional goal of gated ionic signaling that is distinct from that of massive constitutive osmotic water permeability.

  • 4B) shifted from approximately -24 mV in the initial state to about -4 mV in the activated state, consistent with the activation of a non-selective cationic conductance permeable to both Na +and K +. Similar results were observed for other SNP-activated oocytes (n = 5), as well as for AQP1-expressing oocytes activated by prior incubation in 10 mM 8Br-cGMP (as described in [ 11 ] ). In AQP1-expressing oocytes, the conductance induced by 8Br-cGMP in control Na +saline did not change significantly [(+) 11.

  • Activation of the ionic current was induced by preincubation of AQP1-expressing oocytes for 10-30 minutes in 10 mM 8Br-cGMP (Sigma) in high K +saline, containing (in mM): 30 KCl, 80 K gluconate, 5 MgCl 2 , 5 HEPES, pH 7.3, or by addition of 2-4 mM sodium nitroprusside (SNP), a stimulator of guanylate cyclase and cGMP production [ 34 35 ] . Control oocytes treated in the same conditions showed no induction of an ionic current.

  • Meetings of the Device Good Manufacturing Practice Advisory Committee (GMP Advisory Committee) were announced by Federal Register publication on April 25, 1990 (55 Fed.

  • We utilized a newly available somatic cell hybrid technique from GMP Genetics, Inc. [ 9 ] to obtain haploid cell lines.


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