Example sentences for: gmp
How can you use “gmp” in a sentence? Here are some example sentences to help you improve your vocabulary:
They are constitutively permeable to water, and also function as regulated non-selective cation channels [ 10 ] when gated by intracellular cyclic GMP [ 11 12 ] . Even though only a small proportion of the AQP1 channels that are present in the membrane appear to be available for cGMP-activation of the ionic conductance (1/56,000), model-based calculations nonetheless suggest that this contribution could be meaningful in a physiological setting [ 13 ] . Unlike transporters which move substantial amounts of substrate by design, ion channels function to change membrane potential by the net movement of relatively tiny amounts of charge (~10 picomoles per cm 2membrane to generate a change of 100 mV) [ 14 ] , hence the low proportion of active AQP1 ion channels is consistent with a functional goal of gated ionic signaling that is distinct from that of massive constitutive osmotic water permeability.
Meetings of the Device Good Manufacturing Practice Advisory Committee (GMP Advisory Committee) were announced by Federal Register publication on April 25, 1990 (55 Fed.
4B) shifted from approximately -24 mV in the initial state to about -4 mV in the activated state, consistent with the activation of a non-selective cationic conductance permeable to both Na +and K +. Similar results were observed for other SNP-activated oocytes (n = 5), as well as for AQP1-expressing oocytes activated by prior incubation in 10 mM 8Br-cGMP (as described in [ 11 ] ). In AQP1-expressing oocytes, the conductance induced by 8Br-cGMP in control Na +saline did not change significantly [(+) 11.
We utilized a newly available somatic cell hybrid technique from GMP Genetics, Inc. [ 9 ] to obtain haploid cell lines.
Activation of the ionic current was induced by preincubation of AQP1-expressing oocytes for 10-30 minutes in 10 mM 8Br-cGMP (Sigma) in high K +saline, containing (in mM): 30 KCl, 80 K gluconate, 5 MgCl 2 , 5 HEPES, pH 7.3, or by addition of 2-4 mM sodium nitroprusside (SNP), a stimulator of guanylate cyclase and cGMP production [ 34 35 ] . Control oocytes treated in the same conditions showed no induction of an ionic current.
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