Words similar to glucose-stimulated

Example sentences for: glucose-stimulated

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Since K ATP plays a crucial role in glucose-stimulated insulin secretion, PMA-induced hyperpolarization could be mediated by changes in K ATP activity.
Phorbol esters are often used as activators of protein kinase C (PKC) to investigate the role of the kinase in cellular functions [ 1 ] . Pancreatic β-cells possess α, β1, δ and ε PKC isotypes [ 2 ] , and activation of PKC is known to synergize with glucose stimulation in insulin secretion [ 3 4 5 ] . PKC, via protein phosphorylation seems to facilitate exocytosis of insulin granules [ 6 7 8 ] . In glucose-stimulated insulin secretion, ATP-sensitive K +channels (K ATP (SUR1, Kir6.
In primary β-cells from the mouse, activation of PKC by PMA did not cause any change in membrane potential [ 15 16 ] , although in the same cell type, PMA reduced the glucose-stimulated elevation of [Ca 2+] i depending on activation of PKC [ 16 ] . On the other hand, recent studies in myocytes suggest that activation of PKC increases the open-time probability of K ATP (SUR2, Kir6.