Words similar to globulin
Example sentences for: globulin
How can you use “globulin” in a sentence? Here are some example sentences to help you improve your vocabulary:
The sections were then washed in PBS (30 min) and incubated for 60 min at room temperature with biotinylated antirabbit immunogamma globulin diluted 1/200 in PBS.
, [ 10 12 13 14 15 ] ]. It is thought to regulate spermatogenesis and sperm maturation by maintaining high androgen levels in the testis and epididymis [ 16 17 ] and has been proposed as a biochemical marker for Sertoli cell function and formation of blood-testis barrier [ 12 18 ] . More recently, cell surface receptors for ABP and its liver-derived homolog sex hormone-binding globulin (SHBG) were identified in several androgen target tissues, suggesting that these extracellular steroid-binding proteins may have a much broader, hormone-like function [ 19 20 21 ] .
Fiber might affect the risk of breast cancer by decreasing estrogen levels; fiber binds estrogen excreted into the gastrointestinal tract and reduces enterohepatic circulation [ 17 18 ] . In addition, higher dietary fiber intake has been associated with higher plasma levels of sex-hormone-binding globulin, which can reduce the bioavailability of estrogens [ 19 ] . The potential mechanism of a protective effect of vegetable fat is more speculative: vegetable fat is a composite of multiple forms of fatty acids, some of which have been proposed to increase risk (such as C 18:2 n-6) whereas other specific fatty acids have been proposed to decrease risk (such as C 18:1 , the primary fatty acid in olive oil) [ 20 ] . More detail on the type and composition of the vegetable oil used is necessary to pursue this relation with greater precision.
Obesity is also associated with significant hormonal changes such as decreased serum estradiol and sex hormone binding globulin (SHBG) levels, increased peripheral fat conversion of estrogens to progesterone and increased serum testosterone levels that may be associated with an increased risk of breast cancer [ 17 ] . Estrogens are necessary for normal breast development, and they induce and promote mammary tumor growth in animal studies [ 18 ] . In addition, the close association between increased risk of breast cancer and certain reproductive factors such as early menarche and late menopause [ 19 ] , as well as the fall off in the rate of increase in the incidence of disease at menopause [ 20 ] and the lowered risk of breast cancer in oophorectomized women and those taking antiestrogens [ 21 22 ] , all support the role of estrogen in breast carcinogenesis.
BMI = body mass index; LRT = likelihood ratio test; SHBG = sex hormone binding globulin; WHR = waist-hip ratio.
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