Words similar to gln
Example sentences for: gln
How can you use “gln” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although the formation of intranuclear inclusions has not been observed in previous studies of Ras-related GTPases, it is a common feature of several neurodegenerative disorders where abnormal proteins containing poly-Gln tracts are synthesized as a result of CAG codon expansions [ 52 ] . Examples include Huntington's disease (huntingtin) [ 53 54 ] , spinocerebellar ataxia (SCA) types 1 and 3 (ataxin-1 and ataxin-3) [ 55 56 ] and dentatorubral-pallidoluysian atrophy (atrophin-1) [ 57 ] . These poly-Gln protein aggregates typically contain ubiquitin [ 58 ] and members of the Hsp70 chaperone family [ 59 ] , consistent with a proposed pathway for cellular clearance of toxic misfolded proteins.
To examine a wider range of promoter and polymerase combinations, a promoter library was constructed in which positions -8 through -11 in the promoter were completely randomized; each of these nucleotides had previously been shown to be extremely important for the specificity of interactions with T7 RNA polymerase [ 6 7 9 11 ] . Conversely, residues Asn 748, Arg 756, and Gln 758 were known to form sequence specific contacts with this region of the promoter [ 2 ] . The promoter library was combined with the gene library in order to create approximately 51,200 (4 4× 20 3) combinations of promoters and polymerases.
However, there are many case reports describing patients with progressive neurodegenerative disorders of unknown etiology, collectively referred to as neuronal intranuclear inclusion disease [ 77 ] . While these may consist mainly of unidentified poly-Gln or poly-Ala disorders, the present study raises the possibility that some forms of this disease may arise through unexpected mechanisms, perhaps involving mutations in Rab24 or other poorly characterized members of the Rab GTPase family that mediate trafficking of misfolded proteins within autophagosomes and lysosomes.
This change resulted in loss of one Chl b after reconstitution [ 34 ] . Gln 131 ( b 6) and Glu 139 (in an ion-pair with Arg142) ( b 5) were also identified as ligands to Chl b [ 31 34 35 36 ] . Remelli et al.
To test this further, we generated an in-frame deletion of this region, as originally intended, that showed normal function [ 20 ] . Another domain critical for EC coupling is Csk35 downstream from Peptide A (Leu720-Gln765).
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