Words similar to gln
Example sentences for: gln
How can you use “gln” in a sentence? Here are some example sentences to help you improve your vocabulary:
Four residues in the vicinity of the ligands are varying from one receptor isotype to the other: Thr183 of alpha4 (Ser in alpha3 and alpha7), Ala135 of beta2 (Leu in beta4 and Val in alpha7), Phe144 of beta2 (Leu in beta4 and Gln in alpha7), and Thr83 of beta2 (Lys in beta4 and Gln in alpha7) (Figure 1).
Less strong Lewis bases are the charge-compensated Glu in an ion-pair with Arg, the amide group of Gln and Asn, and finally the carbonyl of the peptide backbone as the weakest [ 29 ] . The importance of the ligand was demonstrated by substitution of His with the weaker Lewis base Asn in the apoprotein of the bacterial light-harvesting complex LH1, which eliminated assembly of the complex in vivo and reconstitution in vitro [ 30 ] . Formation of a stable coordination bond with a weaker Lewis base is expected to require a stronger Lewis acid.
Although the formation of intranuclear inclusions has not been observed in previous studies of Ras-related GTPases, it is a common feature of several neurodegenerative disorders where abnormal proteins containing poly-Gln tracts are synthesized as a result of CAG codon expansions [ 52 ] . Examples include Huntington's disease (huntingtin) [ 53 54 ] , spinocerebellar ataxia (SCA) types 1 and 3 (ataxin-1 and ataxin-3) [ 55 56 ] and dentatorubral-pallidoluysian atrophy (atrophin-1) [ 57 ] . These poly-Gln protein aggregates typically contain ubiquitin [ 58 ] and members of the Hsp70 chaperone family [ 59 ] , consistent with a proposed pathway for cellular clearance of toxic misfolded proteins.
To test this further, we generated an in-frame deletion of this region, as originally intended, that showed normal function [ 20 ] . Another domain critical for EC coupling is Csk35 downstream from Peptide A (Leu720-Gln765).
Although this model implies that the misfolded poly-Gln protein might be the primary substrate for ubiquitination, a recent study by Suhr et al . [ 60 ] suggests that this may not always be the case.
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