Words similar to gli
Example sentences for: gli
How can you use “gli” in a sentence? Here are some example sentences to help you improve your vocabulary:
These include: a Hh-protein-blocking antibody, 5E1 [ 23 ] ; a natural product derivative, cyclopamine [ 9 10 ] that has recently been shown to act downstream of Ptc, perhaps at the level of Smo [ 11 ] ; a recently identified synthetic small-molecule inhibitor, Cur61414, which has inhibitory properties similar to cyclopamine [ 17 ] ; and forskolin, an adenylate cyclase/protein kinase A activator that is thought to block Hh signaling by stimulating degradation of members of the Gli family of transcriptional activators [ 2 ] .
In particular, little is known about the means by which Ptc exerts its inhibitory effect on Smo, or how Smo communicates with the cytoplasmic Ci/Gli transcription factor complex.
Additional pathway components are thought to modulate the activity or subcellular distribution of these molecules [ 2 ] . There is positive and negative feedback at the transcriptional level as the Gli1 and Ptc1 genes are direct transcriptional targets of activation of the pathway.
Although no compelling data have been presented that directly link classic G-protein activation [ 37 ] to the canonical Hh pathway involving Ci/Gli stimulation [ 2 ] , recent studies show that under certain conditions Smo can engage G-protein subunits in a Ptc-dependent manner [ 38 ] and that G-protein-mediated cAMP modulation may underlie certain effects of Hh on neuronal tissue [ 39 ] .
After testing several cell lines for Hh-dependent induction of the target genes Ptc1 and Gli1 [ 2 ] , we identified C3H10T1/2 and TM3 cells as optimal responders.
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