Words similar to gleevec

Example sentences for: gleevec

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The concentration of Gleevec to inhibit 50% cell growth (IC50) was estimated to be around 2-3 μM (Figure 1), whereas the IC50 of cisplatin on A549 cells was estimated to be 64-70 μM (Figure 2).
We sought to see if Gleevec can potentiate the cell killing effects of cisplatin, the leading chemotherapeutic drug for almost all advanced cancer patients.
We have chosen to perform the experiments under the normal culture condition since we reasoned that the effect of Gleevec on tumor cells, if any, should be under the normal, not serum free condition.
Gleevec has been shown to induce clinical, hematological and molecular remissions for CML patients [ 4 ] . It cross-reacts with two other important growth factor receptors containing tyrosine kinase domains, c-kit and PDGF receptors, that play important roles in growth and proliferation of a variety of cell types [ 5 ] . C-kit (also known as CD117) is frequently mutated in gastrointestinal stromal tumor (GIST), and the mutated c-kit shows higher tyrosine kinase activity.
Synergistic effect of Gleevec and cisplatin on A549 cells