Example sentences for: gleevec

How can you use “gleevec” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The inhibitory effect of Gleevec on the A549 cells appeared to be in a therapeutic range of the drug as demonstrated in chronic myelogenous leukemia cells from the patients.

  • Treatment of the cells with Gleevec at two concentrations did not influence the expression of PDGFR-α expression in the cells.

  • Existing data suggest that Gleevec can exert its inhibitory effect on tumor cells through inhibiting PDGF receptor function, and we have shown that the primary non-small cells lung cancer expressed minimal c-Kit.

  • Gleevec has been shown to induce clinical, hematological and molecular remissions for CML patients [ 4 ] . It cross-reacts with two other important growth factor receptors containing tyrosine kinase domains, c-kit and PDGF receptors, that play important roles in growth and proliferation of a variety of cell types [ 5 ] . C-kit (also known as CD117) is frequently mutated in gastrointestinal stromal tumor (GIST), and the mutated c-kit shows higher tyrosine kinase activity.

  • These results provided important in vitro data to support the notion that Gleevec can inhibit the A549 cell growth and proliferation, and may potentially offer a treatment option for lung cancer either alone or in conjunction with chemotherapy drug cisplatin.


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