Words similar to gleevec
Example sentences for: gleevec
How can you use “gleevec” in a sentence? Here are some example sentences to help you improve your vocabulary:
Since it has been reported that Gleevec can inhibit the function of PDGFR under the cell culture conditions, it is likely that Gleevec exerts its inhibitory effects on A549 lung cancer cells through inhibiting the PDGFR function.
Synergistic effect of Gleevec and cisplatin on A549 cells
Gleevec was designed to inhibit the BCR-ABL tyrosine kinase, and it cross-reacts with c-kit and PDGFR [ 5 ] . In non-small cell lung cancer, BCR-ABL expression has never been reported, and it is unlikely that BCR-ABL fusion protein plays any role in lung cancer.
One of the major reasons of testing Gleevec for treatment of non-small cell lung carcinoma is to see if the specific tyrosine kinase inhibitor Gleevec, and other potential small molecules currently on clinical trials, can be used as an adjuvant therapeutic agent in combination with conventional chemotherapy.
It has been widely thought, but never been proven that the specific tyrosine kinase inhibitors such as Gleevec can be used as adjuvant therapy in combination with conventional chemotherapy, because the limited clinical trial data suggests only a marginal benefits using this kind of drug to treat the cancer alone (John Rogers, WVU Cancer center, ECOG trial member, personal communication).