Words similar to gleevec

Example sentences for: gleevec

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Since it has been reported that Gleevec can inhibit the function of PDGFR under the cell culture conditions, it is likely that Gleevec exerts its inhibitory effects on A549 lung cancer cells through inhibiting the PDGFR function.
The assay is based upon the cleavage of the yellow tetrazolium salt MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] to purple formazan crystals by metabolically active cells [ 15 ] . The tested concentration of Gleevec ranged from 0.5 to 8 μM.
The concentration of Gleevec to inhibit 50% cell growth (IC50) was estimated to be around 2-3 μM (Figure 1), whereas the IC50 of cisplatin on A549 cells was estimated to be 64-70 μM (Figure 2).
Gleevec inhibited the A549 cell growth in a dose-dependent manner
One of the major reasons of testing Gleevec for treatment of non-small cell lung carcinoma is to see if the specific tyrosine kinase inhibitor Gleevec, and other potential small molecules currently on clinical trials, can be used as an adjuvant therapeutic agent in combination with conventional chemotherapy.