Words similar to glaucoma
Example sentences for: glaucoma
How can you use “glaucoma” in a sentence? Here are some example sentences to help you improve your vocabulary:
Glaucoma is a leading cause of blindness that involves loss of retinal ganglion cells and degeneration of the optic nerve [ 1 ] . Glaucoma is usually associated with high intraocular pressure (IOP) that results from an increased resistance to drainage of the ocular fluid [ 1 ] . Developmental disorders of the ocular anterior segment, including Axenfeld-Rieger syndrome, are often associated with elevated IOP and glaucoma [ 1 2 ] . The developmental sequence and structure of the human and mouse ocular drainage structures are similar [ 3 ] , and the same genes are known to cause anterior segment dysgenesis (ASD) in humans and mice.
Although elevated IOP likely results in inner retinal cell death in glaucoma, deficiency of inner retinal cells in Bmp4 +/-heterozygotes is at least partly a developmental phenomenon.
Mutations in MYOC have been shown to be causative for primary open angle glaucoma (POAG) [ 1 2 3 ] . Glucocorticoids have been implicated in ocular hypertension and glaucoma due to increased plasma cortisol levels [ 4 5 ] and altered cortisol metabolism [ 6 7 ] in POAG patients and from the increased risk of developing POAG in steroid-responsive patients [ 8 9 ] . Myocilin has been shown to be upregulated in glucocorticoid-treated human trabecular meshwork (TM) cells [ 10 11 ] , and there is variable evidence for increased MYOC expression in glaucomatous individuals [ 12 13 14 ] . In addition, glaucoma patients have a higher chance of responding to steroids than non-glaucomatous individuals.
We are particularly interested in documenting differences in glaucoma phenotypes between strains of mice that share the same causative genes.
The IPD phenotype in D2 mice is similar to human pigment dispersion syndrome, a condition that often leads to pigmentary glaucoma [ 12, 13], and involves degeneration of the iris pigment epithelium [ 12, 14].
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