Words similar to gingival
Example sentences for: gingival
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Association of DMFT with gingival health and fluoride in high and low responders
Streptococcus mutans in which DCP is inactive do not initiate growth at below pH 6.5 and make glycerol LTA without D-alanine [ 14 ] . In the DCP active strains, soluble D-Alanyl LTA is extruded into culture fluid in vitro [ 16 17 ] or plaque in vivo [ 18 ] . The D-alanyl esters are stable at pH 6.0 at 37°C, but hydrolyze to free D-alanine and LTA with a half-life of 3.9 h at pH 8.0 [ 19 ] . Healthy gingival sulci have a pH of 6.5 - 7.5 and inflamed sulci a pH of 7.5-8.
Because caries experience associated with fluoride and gingival health in high responders, poor gingival health should increase the number of decayed teeth (DT) more than in low responders.
A number of studies have demonstrated that long treatment of both CsA and TAC is associated many side effects such as nephrotoxicity, hypertension, and gingival hyperplasia [ 1 2 ] . Rapamycin clinically termed, as Sirolimus (SRL) is a new immunosuppressive agent, which is structurally similar to TAC, binds to same binding protein FKBP, but has different mechanism of action [ 3 ] . Both clinical and experimental studies demonstrated that SRL when used either with CsA or alone is associated with side effects like hyperlipidemia, thrombocytopenia and nephrotoxicity [ 4 5 6 7 ] . SRL and TAC compete for the same binding site and hence it was thought they could not be used concomitantly.
The long-term treatment of patients with either CsA or TAC results in side effects such as nephrotoxicity, hypertension, and gingival hyperplasia [ 1 2 ] . Sirolimus (SRL) a new immunosuppressive agent is structurally similar to TAC binds to same binding protein FKBP, but its mechanism of action is different [ 3 ] . Both clinical and experimental studies demonstrated that SRL when used either with CsA or alone is associated with side effects such as hyperlipidemia, thrombocytopenia and nephrotoxicity [ 4 5 6 7 ] . Since SRL and TAC have affinity for the same binding site, it was thought to be ineffective when used together.
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