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Example sentences for: gh
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To identify if alterations at the STSL locus could account for these observations, we amplified and directly sequenced Abcg5 and Abcg8 from Wistar, Sprague-Dawley, WKY, WKA, GH, SHR, and SHRSP rats.
All of these strains are homozygous mutant for Gly583Cys in sterolin-1, encoded by Abcg5 . This mutation is not present in rats that were not sitosterolemic, even though one of these was hypertensive (the GH rat).
Recent linkage mapping studies mapped hypertension QTLs to a number of chromosomal regions in SHR and SHRSP rats [ 35 ] . Our FISH study assigned the STSL locus rat chromosome 6q12, a region where a cluster of blood pressure QTL with Lod score 4~6 has been reported to be present (M6MIT12-M6MIT3, 39 cM distance) in a New Zealand genetically hypertensive rat (GH rat) [ 35 ] . With respect to hypertension, although the SHR and SHRSP strains carry the Gly583Cys mutation, in extensive QTL mapping studies using these strains, no loci mapping to the rat STSL region have been reported [ 35 ] . In our study, the GH rat is neither sitosterolemic, nor has any nucleotide alteration at the STSL locus that would implicate this region as mutated.
The SHR strain was derived by selective inbreeding from the Kyoto outbred Wistar colony, and both SHR and SHRSP, as well as WKY strains have been maintained over many generations through brother-sister matings http://rgd.mcw.edu/tools/strains [ 43 44 ] . Healthy WKA and GH rat strains were also generated from outbred Wistar rat strains, but these strains were isolated independently in Japan and New Zealand, respectively (and maintained at other sites as well).
GH performed all experiments; LZ performed data analysis and assisted in writing the manuscript; DD participated with extensive discussion and direction in experimental design; EH directed all studies including gathering all clinical samples.
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