Example sentences for: germline

How can you use “germline” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • There is a biased use of particular germline VH genes in the VH repertoire.

  • AS = ankylosing spondylitis; CDR = complementarity determining region; DH = heavy chain diversity segment; FR = framework region; GC = germinal centers; gl = germline; JH = heavy chain joining segment; PCR = polymerase chain reaction; RA = rheumatoid arthritis; ReA = reactive arthritis; SM = synovial membrane; VH = heavy chain variable segment.

  • Some of these variants have been independently observed by other groups: NF1ins4a-2 [ 14 15 16 ] , NF1ΔE4b [ 14 15 16 ] , NF1ΔE7 [ 15 19 ] , NF1ΔE29/E30 [ 11 ] , NF1ΔE30 [ 11 ] , NF1ΔE33 [ 16 ] , NF1ΔE34 [ 16 ] , NF1ΔE37 [ 15 16 ] , NF1ΔE43 [ 16 ] , NF1-Δ7605-7675 [ 16 ] and NF1ΔE45 [ 16 ] . Some of these transcripts increased with time or cold shock [ 14 16 ] . It has been shown that ~30 % of NF1 germline mutations result in splicing errors [ 13 20 ] . The vast majority of them are due to alterations outside the canonical AG/GT acceptor and donor splice sites.

  • Indeed, p53 controls the low-level damage-dependent premeiotic checkpoint which facilitates DNA repair during spermatogenesis [ 25 ] . Gametogenesis is inherently error-prone [ 26 ] and subject to mutations [ 27 ] . Nevertheless, it is imperative to avoid genotoxic complications that could become integrated into the germline.

  • . The authors also identify a short, C-terminal domain that makes FOG-2 uniquely able to perform its germline sex-determining function.


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