Words similar to germline
Example sentences for: germline
How can you use “germline” in a sentence? Here are some example sentences to help you improve your vocabulary:
Turcot's syndrome is caused by germline mutations in the gene APC , a member of the Wnt signaling pathway.
Of the sixteen U3 gene trap proviruses selected in ES cells that we have introduced into the germline, six resulted in obvious phenotypes (typically embryonic death) when bred to homozygosity [ 10 21 28 29 30 31 32 ] . In cases where no obvious phenotypes are observed, it is important to determine if the insert did not disrupt gene expression or if the gene is dispensable.
Finally, approximately 40% of inserts selected in ES cells result in obvious phenotypes following transmission into the mouse germline [ 27 28 29 ] . In the four cases examined, the virus appeared to induce null mutations [ 10 30 31 32 ] .
Following pair-wise mating (conjugation), each exconjugant replaces its old parental MAC with a new MAC, developed from a mitotic daughter of its genotypically new zygotic nucleus (review: [ 14 ] ). The mitotic sister of the MAC precursor (anlage) is set aside as the new diploid germline MIC, which is then heterochromatically silenced; all known gene expression is from the MAC or MAC anlage [ 15 16 17 ] . Once the anlage begins differentiation, the old MAC is apoptotically destroyed [ 18 ] . The mature exconjugant resumes feeding and establishes a vegetative clone (a karyonide) propagated by binary fission, in which the MIC replicates as a typical diploid mitotic nucleus and the MAC replicates amitotically.
Germline mutations in the breast and ovarian cancer susceptibility gene BRCA1 , which is located on chromosome 17q21, are associated with a predisposition to the development of cancer in these organs [ 1, 2].
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