Words similar to germline

Example sentences for: germline

How can you use “germline” in a sentence? Here are some example sentences to help you improve your vocabulary:

Most previously analysed mutations were selected because of phenotypes observed after germline transmission, and thus are unlikely to reveal mechanisms that could allow expression of the entrapment vector without disrupting expression of the occupied gene.
Of the sixteen U3 gene trap proviruses selected in ES cells that we have introduced into the germline, six resulted in obvious phenotypes (typically embryonic death) when bred to homozygosity [ 10 21 28 29 30 31 32 ] . In cases where no obvious phenotypes are observed, it is important to determine if the insert did not disrupt gene expression or if the gene is dispensable.
Turcot's syndrome is caused by germline mutations in the gene APC , a member of the Wnt signaling pathway.
Germline mutations in the breast and ovarian cancer susceptibility gene BRCA1 , which is located on chromosome 17q21, are associated with a predisposition to the development of cancer in these organs [ 1, 2].
AS = ankylosing spondylitis; CDR = complementarity determining region; DH = heavy chain diversity segment; FR = framework region; GC = germinal centers; gl = germline; JH = heavy chain joining segment; PCR = polymerase chain reaction; RA = rheumatoid arthritis; ReA = reactive arthritis; SM = synovial membrane; VH = heavy chain variable segment.