Words similar to germline

Example sentences for: germline

How can you use “germline” in a sentence? Here are some example sentences to help you improve your vocabulary:

AS = ankylosing spondylitis; CDR = complementarity determining region; DH = heavy chain diversity segment; FR = framework region; GC = germinal centers; gl = germline; JH = heavy chain joining segment; PCR = polymerase chain reaction; RA = rheumatoid arthritis; ReA = reactive arthritis; SM = synovial membrane; VH = heavy chain variable segment.
Several large scale screens of insertion mutations in mouse embryo-derived stem (ES) cells rely on DNA sequence analysis to select mutations for germline transmission [ 21 22 23 24 ] . The process, designated "tagged sequence mutagenesis", involves sequencing short segments of DNA isolated from each mutation to identify genes disrupted by the targeting vector.
A germline mutation in PTEN is associated with multi-neoplastic, autosomally dominant syndromes in humans, such as Cowden disease and Bannayan-Zonana syndrome (also known as Bannayan-Riley-Ruvalcaba syndrome), and 20-50% of affected females in these families develop breast cancer [ 15, 16, 17].
Five productively rearranged genes were highly mutated with a range of 12 (F5-3a3) to 29 mutations to their respective germline (gl) gene.
From this we were able to conclude that F3 hprt null ES cells are indeed competent to transmit alleles through the germline and that the resulting offspring were fertile and viable as reported previously [ 12 ] .