Words similar to genomewide
Example sentences for: genomewide
How can you use “genomewide” in a sentence? Here are some example sentences to help you improve your vocabulary:
References for the polymorphisms listed in Table 1are provided in the additional file 1. The genomewide screen for a large number of SNP markers may uncover the association of novel polymorphisms with cerebrovascular disease and stroke in sickle cell disease.
The reason is simply that this approach has only recently become possible with the advent of high throughput SNP genotyping and we are not currently aware of any published studies that have used genomewide association for identification of susceptibility loci of complex traits.
The 28 polymorphisms in 20 candidate genes and the SNP markers in the genomewide screen will be genotyped by high-throughput SNP screening using the MassARRAY™ System (Sequenom Inc., San Diego, CA).
Our genomewide association scan aimed at identifying novel polymorphisms associated with stroke risk will necessarily have a somewhat exploratory character.
Initial simulation estimates based on monotonic population expansion suggested that useful LD was unlikely to extend beyond 3 kb, implying a number of 500,000 SNPs necessary for a whole-genome scan [ 32 ] . Another study looking at real data found that LD extended over much larger distances and arrived at an estimate as small as 30,000 SNPs, or 1 SNP per 100 kb [ 33 ] . Recent evidence suggests that the genome consists of blocks of high LD (haplotype blocks) separated by recombination hot spots [ 34 ] . Within each block, a limited number of common haplotypes (three to five) typically capture about 90% of all chromosomes, which means that a reduced number of SNPs would be needed to characterize these haplotypes [ 35 ] . Thus, the recently initiated construction of a haplotype map of the human genome may facilitate selection of SNP markers for genomewide association studies like ours.
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