Words similar to genomewide
Example sentences for: genomewide
How can you use “genomewide” in a sentence? Here are some example sentences to help you improve your vocabulary:
Our genomewide association scan aimed at identifying novel polymorphisms associated with stroke risk will necessarily have a somewhat exploratory character.
Identifying genes for polygenic ischemic stroke has been a difficult task and most human studies have employed a candidate gene approach [ 5 ] although at least one genomewide linkage scan in affected sibling pairs is on the way [ 22 ] . We propose to use a combination of a candidate gene association study and genomewide association scan in children with Hb SS at high (230 cases) or low (400 controls) risk for cerebrovascular disease as determined by their TCD velocity.
The study will consist of two parts, a candidate gene study and a genomewide screen and will be performed in 230 cases and 400 controls.
Design of DNA pooling for genomewide association screen
Initial simulation estimates based on monotonic population expansion suggested that useful LD was unlikely to extend beyond 3 kb, implying a number of 500,000 SNPs necessary for a whole-genome scan [ 32 ] . Another study looking at real data found that LD extended over much larger distances and arrived at an estimate as small as 30,000 SNPs, or 1 SNP per 100 kb [ 33 ] . Recent evidence suggests that the genome consists of blocks of high LD (haplotype blocks) separated by recombination hot spots [ 34 ] . Within each block, a limited number of common haplotypes (three to five) typically capture about 90% of all chromosomes, which means that a reduced number of SNPs would be needed to characterize these haplotypes [ 35 ] . Thus, the recently initiated construction of a haplotype map of the human genome may facilitate selection of SNP markers for genomewide association studies like ours.
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