Words similar to gefitinib
Example sentences for: gefitinib
How can you use “gefitinib” in a sentence? Here are some example sentences to help you improve your vocabulary:
However, three additional patients with clinical resistance to gefitinib or erlotinib did not have the T790M mutation, nor did they have mutant KRAS alleles that have previously been shown by these same authors to confer resistance to these inhibitors [9].
The related compound, gefitinib, is predicted to interact with this threonine residue as well.
Cells (in supplemented RPMI-1640 medium containing 0.1% serum) were then incubated for 48 h in the continued presence of gefitinib or erlotinib.
We sought to determine whether KRAS mutations could also be used to predict primary sensitivity or resistance to gefitinib or erlotinib.
We identified 60 lung adenocarcinomas from individual patients with tumors shown to be sensitive or refractory to single-agent gefitinib or erlotinib and evaluated these tumors for mutations in EGFR and KRAS . Collectively, nine of 38 (24%) tumors refractory to either kinase inhibitor had KRAS mutations, while zero of 21 (0%) drug-sensitive tumors had such mutations ( p = 0.02) (Table 1).