Words similar to gcts

Example sentences for: gcts

How can you use “gcts” in a sentence? Here are some example sentences to help you improve your vocabulary:

Our current observation that undetectable levels of MGMT gene expression in >95% of GCTs appears to suggest that the lack of the O(6)-methylguanine-DNA methyltransferase enzyme may direct cells to undergo apoptosis due to failure of repair of DNA adducts formed by alkylating agents.
Thus in these cases, promoter hypermethylation is one mechanism whereby gene expression can be deregulated in GCTs.
These data, thus, showed loss of MGMT expression in majority of GCTs of all histologic subsets.
Epigenetic mechanisms of gene silencing are increasingly being recognized to affect a number of molecular pathways in human cancer [ 12 ] . The extent and the nature of such epigenetic modifications in GCTs are currently poorly understood.
It has been shown that engineered over-expression of wild-type p53 in vitro causes inhibition of MGMT transcription in human tumor cells [ 29 ] . Abundant over-expression of wild-type p53, owing to their stage of origin, is a characteristic feature of GCTs [ 30 ] . A possibility also exists that the MGMT expression may, in general, be down regulated in tumors arising from embryonic-type cells.