Words similar to gcts

Example sentences for: gcts

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It has been shown that engineered over-expression of wild-type p53 in vitro causes inhibition of MGMT transcription in human tumor cells [ 29 ] . Abundant over-expression of wild-type p53, owing to their stage of origin, is a characteristic feature of GCTs [ 30 ] . A possibility also exists that the MGMT expression may, in general, be down regulated in tumors arising from embryonic-type cells.
Lack of MGMT expression in the majority of GCTs suggests a potential role for this protein in lack of repair of cisplatin-induced DNA damage that may result in exquisite sensitivity in this tumor.
Epigenetic mechanisms of gene silencing are increasingly being recognized to affect a number of molecular pathways in human cancer [ 12 ] . The extent and the nature of such epigenetic modifications in GCTs are currently poorly understood.
The data also suggest that multiple mechanisms, in addition to the promoter methylation, may play a role in silencing of MGMT gene expression in GCTs of all histologic subsets.
To determine whether the down-regulated expression of the MGMT gene is due to genetic mutations, we examined the entire coding region in 30 GCTs and found no inactivating mutations (unpublished observations).