Words similar to gcts

Example sentences for: gcts

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NSGCTs display complex differentiation patterns that include embryonal, extra-embryonal, and somatic tissue types [ 6 ] . Teratomas with somatic differentiation can undergo additional malignant transformation with characteristics of epithelial, mesenchymal, neurogenic, or hematologic tumors [ 7 ] . While the majority of GCTs exhibit exquisite sensitivity to cisplatin-based chemotherapy, a small proportion of metastatic tumors remain resistant.
Thus in these cases, promoter hypermethylation is one mechanism whereby gene expression can be deregulated in GCTs.
To determine whether the down-regulated expression of the MGMT gene is due to genetic mutations, we examined the entire coding region in 30 GCTs and found no inactivating mutations (unpublished observations).
The data also suggest that multiple mechanisms, in addition to the promoter methylation, may play a role in silencing of MGMT gene expression in GCTs of all histologic subsets.
These data, thus, showed loss of MGMT expression in majority of GCTs of all histologic subsets.