Words similar to gcts

Example sentences for: gcts

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NSGCTs display complex differentiation patterns that include embryonal, extra-embryonal, and somatic tissue types [ 6 ] . Teratomas with somatic differentiation can undergo additional malignant transformation with characteristics of epithelial, mesenchymal, neurogenic, or hematologic tumors [ 7 ] . While the majority of GCTs exhibit exquisite sensitivity to cisplatin-based chemotherapy, a small proportion of metastatic tumors remain resistant.
Thus in these cases, promoter hypermethylation is one mechanism whereby gene expression can be deregulated in GCTs.
7%) GCTs studied with an individual gene frequency of: RASSF1A , 21.
The data also suggest that multiple mechanisms, in addition to the promoter methylation, may play a role in silencing of MGMT gene expression in GCTs of all histologic subsets.
Our current observation that undetectable levels of MGMT gene expression in >95% of GCTs appears to suggest that the lack of the O(6)-methylguanine-DNA methyltransferase enzyme may direct cells to undergo apoptosis due to failure of repair of DNA adducts formed by alkylating agents.