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Example sentences for: gcts

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Therefore, male GCTs comprise a unique model system to investigate the biology and genetics of GC transformation, differentiation, and chemotherapy resistance/sensitivity [ 6 ] .
7%) GCTs studied with an individual gene frequency of: RASSF1A , 21.
These data, thus, showed loss of MGMT expression in majority of GCTs of all histologic subsets.
To determine whether the down-regulated expression of the MGMT gene is due to genetic mutations, we examined the entire coding region in 30 GCTs and found no inactivating mutations (unpublished observations).
It has been shown that engineered over-expression of wild-type p53 in vitro causes inhibition of MGMT transcription in human tumor cells [ 29 ] . Abundant over-expression of wild-type p53, owing to their stage of origin, is a characteristic feature of GCTs [ 30 ] . A possibility also exists that the MGMT expression may, in general, be down regulated in tumors arising from embryonic-type cells.