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Example sentences for: gcdca

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Incubation of the BN clones with GCDCA increased the LDH activity in the culture medium to a level similar to that in the medium of GCDCA-treated McNtcp.
24 cells [ 1 ] concordant with what has been documented in hepatocytes [ 19 ] . Consistent with the induction of apoptotic cell death; GCDCA, but not TCA, preferentially induced the activation of the initiator caspase 8 in McNtcp.
24 cells increased by 20 to 31% within 2 h of incubating the cells in medium containing 100 μM of glycine conjugates of cholic acid, chenodeoxycholic acid, and deoxycholic acid (GCA, GCDCA, GDCA, respectively) (Figure 4A).
24 cells and primary mouse hepatocytes, through activation of the Fas receptor in a FasL-independent manner [ 19 25 ] . Moreover, GCDCA was demonstrated to activate both initiator and effector caspases, and that the apoptotic response can be blocked by Crm A, a caspase 8 inhibitor [ 25 ] . The mechanism by which bile acids stimulate the activation of Fas receptor remains unclear.
GCDCA was the most potent in inducing the release of LDH among the bile acids tested whereas TCA had little effect as compared to the no addition controls.