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Example sentences for: gambian

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There are six pairs of SNPs that are in the coupling phase in the Malawian sample, but are in the repulsion phase in The Gambian sample, reversing the allelic associations.
The 'star-shaped' genealogy of the Gambian TNF locus, dominated by one central haplotype with many derived haplotypes defined by single mutational events, produces negative disequilibria between most pairs of SNPs (the rare alleles are found in the repulsion phase).
For example, in the Gambian sample, allele pairs in the repulsion phase are much more likely to be inefficient markers (where inefficient means the apparent relative risk at the marker SNP is betwen 0.5 and 2.0 when the relative risk of the hypothetical disease SNP is 10) than alleles in the coupling phase ( p < 10 -7).
For example, if the risk at SNP TNF+851 was 10, then the neighboring SNP, TNF+467, would give a relative risk of 3.7 in Malawi, but in the Gambian population, the effect would be protective with a relative risk of 0.8.
Allele frequencies for each SNP are listed in Table 1. The Gambian genotypic data had 354/2,544 (14%) sites where gametic phase was unknown, and the Malawian data had 188/1,008 (19%) sites where gametic phase was unknown.