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Example sentences for: gambiae
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As shown in Figures 2and 4, a substantial proportion of non-coding sequences are conserved in Drosophila , especially in pairwise comparisons between D. melanogaster and D. erecta . Levels of conservation appear to plateau in more divergent comparisons, with a tendency for D. pseudoobscura to show higher levels of non-coding conservation relative to D. willistoni or D. littoralis in pairwise comparisons with D. melanogaster . Few, if any, non-coding sequences are conserved between D. melanogaster and A. gambiae (Figure 4, see also [ 23]).
We were also able to identify the full-length genomic sequence of mosquito COP1 (Anopheles gambiae COP1 , AgCOP1 ) and partial genomic sequences of MmCOP1 and fugu COP1 (Fugu rubripes COP1 , FrCOP1 ). The genomic structures of the vertebrate COP1 genes appear to be generally conserved among themselves, but different from mosquito and plant COP1 genes (data not shown).
Three Runt domain genes in the A. gambiae genome and two previously unidentified Runt domain genes in the D. melanogaster genome were found by TBLASTN search using the S. purpuratus Runt protein sequence as the query.
At the other extreme, using A. gambiae genome sequences may not substantially aid comprehensive genome annotation, as a large proportion of Drosophila genes may not be present in the Anopheles genome and the lack of non-coding conservation between these groups (Figure 7and [ 23]) means that this powerful source of data is unavailable for cis -regulatory annotation.
However, analysis of the Anopheles gambiae (mosquito) genome revealed a gene (EAA06693) located on chromosome X that encodes a 109 amino acid protein (agCP13665) containing a TOX-like HMG-box motif (Fig.
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