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Example sentences for: gambiae
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3%), had no clear homolog in A. gambiae . Five D. melanogaster genes - the four members of the Rhodopsin gene family and CG5245 - have multiple HSPs in the A. gambiae genome sequences.
These results are consistent with previous reports comparing the locations of genes in D. melanogaster with A. gambiae , which indicate that extensive genome rearrangement has occurred since the divergence of these two lineages [ 23, 31, 32].
As shown in Figures 2and 4, a substantial proportion of non-coding sequences are conserved in Drosophila , especially in pairwise comparisons between D. melanogaster and D. erecta . Levels of conservation appear to plateau in more divergent comparisons, with a tendency for D. pseudoobscura to show higher levels of non-coding conservation relative to D. willistoni or D. littoralis in pairwise comparisons with D. melanogaster . Few, if any, non-coding sequences are conserved between D. melanogaster and A. gambiae (Figure 4, see also [ 23]).
The homology of Muller's elements can be extended to A. gambiae [ 23, 31]; however it is clear that a substantial fraction of rearrangements between these species must occur by other mechanisms than paracentric inversion.
We then searched for homologs of these selected regions in Anopheles gambiae using WU-BLAST of the Dm sequence [ 42 ] , extending the returned sequences as necessary on their 5' and 3' ends to make 100-nucleotide windows equivalent to the queried sequence.