Words similar to gain-of-function

Example sentences for: gain-of-function

How can you use “gain-of-function” in a sentence? Here are some example sentences to help you improve your vocabulary:

Briefly, if this model is applied to Hh signaling, it proposes that, firstly, agonist and antagonists act at independent sites to select active and inactive conformations of Smo; secondly, that Smo engages an undefined coupler/effector, when it is in its signaling state; and finally, that the gain-of-function mutant form of Smo, Smo act, adopts an abnormal conformation that resembles the coupler/effector-bound signaling state of Smo with low affinity for antagonists but normal affinity for the agonist.
Furthermore, the gain-of-function Smo mutation renders the protein less sensitive to the inhibitors, presumably because the amino-acid substitution directly stabilizes or induces an active conformation.
CFI1 ) [ 15 16 17 ] and that TAB6 is a gain-of-function mutation in CDC14 [ 18 ] . Net1 sequesters Cdc14 in the nucleolus and inactivates it in preanaphase cells.
A ribbon structure of erlotinib bound to the EGFR kinase domain (Figure 1) shows the threonine residue at position 790 in green and the positions of the exon 19 and L858R gain-of-function mutations.
Rabbits may provide an in vivo system for modeling some aspects of glaucoma, such as steroid induced ocular hypertension [ 23 24 25 26 27 ] and the gain-of-function hypothesis in POAG [ 42 ] .