Words similar to gain-of-function

Example sentences for: gain-of-function

How can you use “gain-of-function” in a sentence? Here are some example sentences to help you improve your vocabulary:

This may be important for examining the effects of expressing gain-of-function or dominant-negative alleles of a gene product.
This procedure is an important addition to the available repertoire of molecular genetic techniques available to developmental biologists because it overcomes several deficiencies associated with alternative transient transgenic approaches normally used to study gain-of-function and dominant-negative alleles.
Flies with gain-of-function mutations in the Antennapedia ( Antp ) gene cannot grow normal antennae, but instead make extra legs with their antennal cells.
The recessive tab mutants are likely to represent reduction-of-function mutations in genes that inhibit exit from mitosis, and the dominant TAB mutants are likely to result from gain-of-function mutations in genes that promote exit from mitosis.
Briefly, if this model is applied to Hh signaling, it proposes that, firstly, agonist and antagonists act at independent sites to select active and inactive conformations of Smo; secondly, that Smo engages an undefined coupler/effector, when it is in its signaling state; and finally, that the gain-of-function mutant form of Smo, Smo act, adopts an abnormal conformation that resembles the coupler/effector-bound signaling state of Smo with low affinity for antagonists but normal affinity for the agonist.