Words similar to gain-of-function

Example sentences for: gain-of-function

How can you use “gain-of-function” in a sentence? Here are some example sentences to help you improve your vocabulary:

Furthermore, the gain-of-function Smo mutation renders the protein less sensitive to the inhibitors, presumably because the amino-acid substitution directly stabilizes or induces an active conformation.
This may be important for examining the effects of expressing gain-of-function or dominant-negative alleles of a gene product.
Briefly, if this model is applied to Hh signaling, it proposes that, firstly, agonist and antagonists act at independent sites to select active and inactive conformations of Smo; secondly, that Smo engages an undefined coupler/effector, when it is in its signaling state; and finally, that the gain-of-function mutant form of Smo, Smo act, adopts an abnormal conformation that resembles the coupler/effector-bound signaling state of Smo with low affinity for antagonists but normal affinity for the agonist.
Excess GC activity due to LIFR loss is an unexpected result since LIF gain-of-function mice develop a Cushing's-like syndrome [ 29 30 ] . Thus, if the relationship were simple, loss of LIFR function would predict development of GC insufficiency.
This procedure is an important addition to the available repertoire of molecular genetic techniques available to developmental biologists because it overcomes several deficiencies associated with alternative transient transgenic approaches normally used to study gain-of-function and dominant-negative alleles.