Example sentences for: gain-of-function

How can you use “gain-of-function” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Rabbits may provide an in vivo system for modeling some aspects of glaucoma, such as steroid induced ocular hypertension [ 23 24 25 26 27 ] and the gain-of-function hypothesis in POAG [ 42 ] .

  • Flies with gain-of-function mutations in the Antennapedia ( Antp ) gene cannot grow normal antennae, but instead make extra legs with their antennal cells.

  • The agonist, on the other hand, would be predicted to bind to a site on Smo that is not affected by this gain-of-function Smo actmutation.

  • Such a model cannot accommodate our observations with the gain-of-function Smo mutant.

  • Somatic gain-of-function mutations in exons encoding the epidermal growth factor receptor (EGFR) tyrosine kinase domain are found in about 10% of non-small cell lung cancers (NSCLCs) from the United States [1,2,3], with higher percentages observed in east Asia [2,4,5,6].


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