Words similar to gain-of-function

Example sentences for: gain-of-function

How can you use “gain-of-function” in a sentence? Here are some example sentences to help you improve your vocabulary:

Briefly, if this model is applied to Hh signaling, it proposes that, firstly, agonist and antagonists act at independent sites to select active and inactive conformations of Smo; secondly, that Smo engages an undefined coupler/effector, when it is in its signaling state; and finally, that the gain-of-function mutant form of Smo, Smo act, adopts an abnormal conformation that resembles the coupler/effector-bound signaling state of Smo with low affinity for antagonists but normal affinity for the agonist.
Although genetic manipulations involving gain-of-function point mutations of Smo [ 3 ] have demonstrated that the pathway can be activated independently of Hh ligand, no small molecules with this capability have been identified.
Such a model cannot accommodate our observations with the gain-of-function Smo mutant.
This may be important for examining the effects of expressing gain-of-function or dominant-negative alleles of a gene product.
Genetic alterations such as amplification, deletion, translocation and rearrangement could result in either gain-of-function or loss-of-function mutations in genes that modulate aspects of cell proliferation, differentiation, motility and survival.