Words similar to gain-of-function

Example sentences for: gain-of-function

How can you use “gain-of-function” in a sentence? Here are some example sentences to help you improve your vocabulary:

Rabbits may provide an in vivo system for modeling some aspects of glaucoma, such as steroid induced ocular hypertension [ 23 24 25 26 27 ] and the gain-of-function hypothesis in POAG [ 42 ] .
The agonist, on the other hand, would be predicted to bind to a site on Smo that is not affected by this gain-of-function Smo actmutation.
Briefly, if this model is applied to Hh signaling, it proposes that, firstly, agonist and antagonists act at independent sites to select active and inactive conformations of Smo; secondly, that Smo engages an undefined coupler/effector, when it is in its signaling state; and finally, that the gain-of-function mutant form of Smo, Smo act, adopts an abnormal conformation that resembles the coupler/effector-bound signaling state of Smo with low affinity for antagonists but normal affinity for the agonist.
In theory, tab mutants could act downstream of or parallel to CDC15, and could be either loss-of-function mutations in genes that inhibit exit from mitosis or gain-of-function mutations in genes that promote exit from mitosis.
This may be important for examining the effects of expressing gain-of-function or dominant-negative alleles of a gene product.