Example sentences for: fzs

How can you use “fzs” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To evaluate whether Fzs are required for the transduction of Wnt/Wg signaling in the presence of LRPs, we have established a sensitive method to measure Wg signaling activities using a LEF-luciferase reporter in Drosophila S2 cells.

  • In addition, LRP6 has been reported to bind Wnt-1 and to associate with Fz in a Wnt-dependent manner [ 8 ] . Taken together, these results support a co-receptor model: upon exposure to Wnts, LRP5 or LRP6 forms a complex with Wnt and Fzs, transducing the Wnt signal downstream to stabilize cytoplasmic β-catenin.

  • Fzs can recruit Dsh to the plasma membrane [ 21 26 ] , but it is not known whether this recruitment is essential in signaling.

  • However, a short conserved cytoplasmic motif in the carboxylterminal region of Fzs, including DFz2, was reported to be important for the activation of Wnt/β-catenin signaling in mammalian cells, based on mutational analysis [ 20 ] .

  • Alternatively, however, it is possible that Wnt/Wg can signal through LRP/Arr in the absence of Fzs.


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