Example sentences for: fxr

How can you use “fxr” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • With the recent discovery that bile acids represent the natural ligands for the nuclear receptor FXR [ 10 11 12 ] , there is heightened interest in identifying the genes that are regulated by bile acids.

  • Recently, it was discovered that bile acids are the natural ligands for a nuclear receptor termed farnesoid x receptor (FXR; NR1H4) [ 10 11 12 ] . Therefore, bile acids may be important regulators of gene expression in the liver and intestines.

  • A number of RXR heterodimer complexes have been categorized as either permissive or non-permissive based on their responses to RXR ligands [ 1 ] . Although there are some reported discrepancies, the PPAR, FXR and NGF-IB/NURR1 complexes are generally considered permissive, while the non-permissive group includes the RAR, TR and VDR complexes (see [ 2 3 4 5 6 7 ] ). In the permissive complexes, coactivators can presumably bind to the AF-2 surface of both partners and binding to the RXR partner is stimulated by rexinoid agonists.

  • To date, the genes that have been shown to be responsive to regulation by FXR encode proteins involved in the biosynthesis and transport of bile acids [ 13 ] . Bile acids have been shown to modulate a variety of other cellular functions, such as secretion of lipoproteins from hepatocytes [ 14 15 ] and translocation of bile acid transporters to the hepatocyte canalicular membrane [ 16 ] . In McNtcp cells, which are liver-derived cells engineered to transport bile acids actively [ 17 ] , taurine-conjugated bile acids induce the formation of intracellular vesicles that resembles structures observed in cholestatic liver cells without apparent cellular cytotoxicity [ 1 18 ] . In contrast, glycine-conjugated bile acids promote apoptosis in these cells [ 19 ] . Thus, different classes of conjugated bile acids stimulate distinctive responses in McNtcp cells.

  • This finding is different from two RNA-binding proteins, FXR1P and FXR2P, that were identified through their interaction with another polysomal-associated RNA-binding protein, the fragile X mental retardation protein [ 21 ] . Both FXR1P and FXR2P are associated with the polyribosomes [ 22 ] .


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