Words similar to functional
- full
- full-absorption
- full-time
- fullest
- fun-loving
- fun-words
- funa
- funan
- funchain
- funchal
- function
- function-blocking
- function-prediction
- functional
- functional--if
- functional-looking
- functional-positional
- functional-property
- functionalism
- functionally
- functionalsnps
- functioning
- functions
- fund
- fundamentally
- funded
- funding
- funds
Example sentences for: functional
How can you use “functional” in a sentence? Here are some example sentences to help you improve your vocabulary:
This database includes a manually curated catalogue of binary protein-protein interactions that is considered to be a reliable reference set [ 12 ] . Protein-protein interactions for the H. pylori proteome [ 7 ] were taken from the PIMRider functional proteomics software platform http://pim.hybrigenics.fr/pimrider/pimriderlobby/PimRiderLobby.jsp.
AtCOP1 contains three conserved structural domains: a RING finger at the amino terminus, a coiled-coil domain in the middle, and a carboxyl-terminal WD40 repeat domain [ 9 10 ] . Each of the three conserved domains has been shown to mediate protein-protein interactions [ 11 12 13 ] . The subcellular localization of AtCOP1 is regulated by light in a tissue specific manner [ 14 15 ] . The hypocotyl cell nuclei contain high levels of COP1 in the dark and reduced levels in the light, suggesting that the nucleocytoplasmic partitioning of AtCOP1 is adjusted by a light-responsive mechanism [ 14 16 ] . The activity of AtCOP1 is at least in part regulated by its subcellular localization, as the degradation of HY5 is dependent upon the nuclear accumulation of AtCOP1 in the dark [ 4 ] . AtCOP1 was demonstrated to carry a single, bipartite nuclear localization signal located between the coiled-coil domain and the WD-40 domain (amino acid 294-314) and a cytoplasmic localization signal, which was mapped to a region partially overlapping with the RING finger and the coiled-coil domain (amino acid 67-117) [ 17 ] . Strikingly, AtCOP1 protein forms characteristic nuclear speckles when transiently expressed in onion epidermal cells or stably expressed in transgenic Arabidopsis [ 6 18 ] . The functional role of these speckles is currently unknown; however, a subnuclear localization signal consisting of 58 residues (amino acid 120-177) is required for their formation [ 19 ] .
However, many of the defects caused by gp130 loss are shared by mice with a null mutation of LIFR, reflecting the heterodimeric relationship of LIFR and gp130 for functional LIFR:gp130 signaling.
Functional annotation
It is becoming increasingly evident that BMP signaling is regulated not only by the spatiotemporal expression of BMP ligands and receptors, but also by relative levels of soluble BMP antagonists, which directly bind BMPs and prevent functional receptor/ligand interaction [ 1 24 25 26 27 28 ] . The different BMP antagonists bind to BMPs and other TGF-β family members with varying degrees of specificity.
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