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Example sentences for: fults

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Recent experiments by Fults and colleagues support the idea that stabilized β-catenin expression in the postnatal CNS is not sufficient to initiate tumor formation [ 36 ] . Using the RCAS-TVA system they showed that overexpression of c-myc, but not of activated β-catenin, promoted the proliferation of neural progenitor cells in vivo and in vitro . In their in vivo experiments expression was initiated in nestin positive cells postnatally via injection of β-catenin stabilized by a point mutation in codon 37.
Alternatively, the contrast between the in utero cortical changes reported by Chenn and Walsh and the lack of a CNS phenotype in our mice or those of Fults could indicate that the developmental stage of the neuroepithelial cells in which stabilized β-catenin is expressed is critical.