Words similar to full-term
Example sentences for: full-term
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Because two studies have noted higher estrogen levels among women with A2 alleles [ 4 23 ] , it is possible that women with these genotypes have more lifetime exposure to circulating steroid hormones that is not abrogated by later age at menarche or by earlier age at first full-term pregnancy.
The evidence that adolescent diet may affect the risk of breast cancer derives from several lines of evidence [ 1 ] . Rates of breast cancer among Asian immigrants to the United States do not approach those of US white women until the second or third generation, suggesting that exposures during childhood and adolescence are important in establishing a higher risk of breast cancer [ 2 3 ] . Norwegian women who were adolescents during World War II, when average caloric intake decreased by 22%, have a reduced incidence of breast cancer, suggesting that energy restriction might affect risk [ 4 ] . Similarly, in animal models, energy restriction in the peripubertal period inhibits mammary tissue proliferation and reduces the subsequent risk of mammary tumors [ 5 6 ] . Exposure of rats to carcinogens before first pregnancy increases the incidence of mammary tumors compared with exposure after first pregnancy [ 7 ] . After differentiation of the mammary gland at the time of first full-term pregnancy of the rat, the rate of cell division decreases and length of the cell cycle increases, allowing more time for DNA repair [ 8 ] . This biologic phenomenon might explain the apparent vulnerability of the adolescent breast tissue to carcinogenic exposures.
While effects of age at menarche, age at first full-term pregnancy, and oral contraceptive use were only significantly notable among premenopausal women with A1 alleles, interactions were not statistically significant (data not shown).
According to details in the NYT piece, the "donor" of the frozen egg that produced the twins was paid about $46,000, or almost five times the going rate for a full-term surrogate pregnancy.
For postmenopausal women, it was women with A2 alleles who were most at risk of breast cancer with late age at first full-term pregnancy and with difficulty becoming pregnant.
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