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Example sentences for: fti-

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FTI-1, an inhibitor of farnesyl transferase also known as L-744,832 [59], mimicked and potentiated statin-activated shedding, presumably by blocking transfer of isoprenoid moieties to a Rho protein by farnesyl transferase, and thereby decreasing Rho activity.
FTI-1 increased the shedding of sAPP α , but the combination of a statin plus FTI-1 increased sAPP α shedding to levels greater than those achievable by using either compound alone (Figure 3; p < 0.05).
To test whether statin-activated shedding might be attributable to a metabolite downstream of HMGCoA reductase, cells were treated with 1 μM simvastatin, 5 μM FTI-1, and a series of concentrations of mevalonic acid.
As predicted, the shedding observed following treatment with FTI-1 was not inhibited by any of the concentrations of mevalonic acid tested (Figure 4).
We therefore tested the effects of FTI-1 on statin-stimulated sAPP α shedding.