Words similar to fs-α
Example sentences for: fs-α
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The skeletal nature of the EC coupling expressed by fs-α 1S is shown in Fig.
Earlier studies in the voltage-gated Na +channel had shown that pore function was not compromised when the II-III linker or III-IV linker was cut and the two fragments were coexpressed each in a separate vector [ 37 ] . We would thus conclude that in the case of the Ca 2+channel, an intact II-III loop is essential for this function since neither fs-α 1S nor the combined expression of the two truncated fragments (not shown) was able to rescue Ca 2+current.
This phenomenon has been described in eukaryotic cells and in viral-infected mammalian cells and is known as translation by leaky ribosomal scanning [ 32 33 ] . To test this explanation, the presumptive restart condon, Met701, was mutated to Ile701 in the fs-α 1S template.
Thus we are certain that the EC coupling expressed by fs-α 1S is mechanistically similar to control skeletal-type EC coupling but limited in magnitude by a comparatively lower density of functional DHPRs that are assembled in cells expressing fs-α 1S . It is conceivable that the functional integrity of the fragmented α 1S protein is maintained in part by the β subunit of the DHPR which spans both halves of the α1 pore subunit by binding to the I-II loop and the C-terminus [ 35 36 ] . Consistent with this explanation, we failed to detect EC coupling recovery when fs-α 1S was expressed in β1-null myotubes.
In some cases, reassembly of a new ribosomal initiation complex after the terminator codon of the leader ORF serves to re-initiate translation at the initiator AUG codon for the main ORF, and thus two proteins are generated [ 39 ] . In other cases, leaky scanning by the ribosomal initiation complex bypasses the 5'-located leader ORF entirely, and only the "internal" ORF is translated [ 32 ] . In the case of fs-α 1S , we are not entirely certain which mechanism best applies.
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