Words similar to fs-α
Example sentences for: fs-α
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Thus we are certain that the EC coupling expressed by fs-α 1S is mechanistically similar to control skeletal-type EC coupling but limited in magnitude by a comparatively lower density of functional DHPRs that are assembled in cells expressing fs-α 1S . It is conceivable that the functional integrity of the fragmented α 1S protein is maintained in part by the β subunit of the DHPR which spans both halves of the α1 pore subunit by binding to the I-II loop and the C-terminus [ 35 36 ] . Consistent with this explanation, we failed to detect EC coupling recovery when fs-α 1S was expressed in β1-null myotubes.
However, when myotubes were cotransfected with fs-α 1S M701I and α 1S Δ1-700, each in a separate pSG5 vector, there was a robust recovery of Ca 2+transients in 5 of 5 cells.
6B) shows that the signal generated by fs-α 1S was significantly smaller than that generated by the control construct (wt-α 1S vs. fs-α 1S t-test significance p = 0.014) and smaller than that generated by the two coexpressed fragments (fs-α 1S vs. fs-α 1S M701I + α 1S Δ1-700 t-test significance p = 0.013).
The magnitude of the Ca 2+transient expressed by fs-α 1S M701I + α 1S Δ1-700 was indistinguishable from that of wt-α 1S (t-test significance p = 0.671, see figure legend).
6C) favor the explanation that 1) fs-α 1S recovers DHPR function by virtue of expressing two complementary fragments of α 1S and 2) the expression of the C-terminal half of α 1S by fs-α 1S is likely to occur by leaky ribosomal scanning.
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