Words similar to frontal
Example sentences for: frontal
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In this regard, it is known that the hormonal action of estrogens may be mediated by the differential expression of estrogen receptors alpha vs betta in brain structures that activate or inhibit cell death mechanisms [ 56 ] . Although, this parameter was not directly investigated in this study, the differing influence that dietary phytoestrogens had on CALB (significant decrease) and COX-2 (significant increase) in the male frontal cortex, suggests that phytoestrogens may activate programmed cell death.
However, when the frontal cortex and cerebellum were examined, where an abundance of ER-β receptors are present, Phyto-600 males displayed a 47-fold and 9-fold higher phytoestrogens levels, respectively, compared to Phyto-free male values.
These results are presented in figure 7. This suggests that high levels of dietary phytoestrogens significantly increased the abundance of COX-2 in the male rat frontal cortex.
, daidzein, genistein and equol) were determined in tissues isolated from the frontal cortex and hippocampus (brain structures critical for VSM) along with the amygdala and cerebellum brain regions, by time-resolved fluoroimmunoassay (TR-FIA) using standard methods based on previously published and validated methods for plasma and urine [ 59 60 ] . The brain tissue method (in brief) follows: The brain samples were lyophilized (pooled by treatment, n = 4 per group) from male rats used as breeders that were on the diet treatments from 50 to 120 days of age.
As CALB plays an important role in regulating intraneuronal cellular calcium, which protects against neurodegenerative disease and defends against apoptosis [ 48 49 50 51 52 ] , a decrease in frontal cortex CALB may result in cognitive impairment due to cell death or abnormal calcium homeostasis [ 48 49 50 51 52 ] . Furthermore, frontal cortical COX-2 was shown to significantly increase in males fed the Phyto-600 diet.
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