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Example sentences for: fridovich

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Fridovich and colleagues first noticed the presence of SOD1 in the intermembrane space in liver mitochondria [ 37 ] . Although this was disputed later [ 38 39 ] , recent experiments in yeast and mammalian cells reaffirmed the presence of both wild type and mutant SOD1 in the intermembrane space of mitochondria [ 21 25 26 40 ] . This finding suggests that mutant SOD1 could directly damage mitochondria by its toxicity.
Since some of these enzymes function in the citric acid cycle (also called the Krebs cycle) and in amino acid biosynthesis, high levels of O 2 − lead to a requirement for certain amino acids in growth media (Imlay and is well known Fridovich 1991).