Example sentences for: frataxin

How can you use “frataxin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Both proteolytic cleavage (via MPP and/or IMP complexes) and chaperonin help (mt-HSP70/Ssc2p) in membrane trafficking and/or folding are needed for the mature frataxin protein to arrive at its destination in the matrix in its proper conformation.

  • The shortage of frataxin does not result from formation of mutant proteins, but rather from expansion of a GAA repeat in the first intron of the frataxin gene.

  • Normal mitochondrial iron homeostasis minimally depends on wild-type frataxin to control efflux.

  • Lack of frataxin protein causes a build-up of iron in the matrix spaces of the mitochondria.

  • Yfh1p (YDL120W), the frataxin homolog in yeast, interacts with the yeast mitochondrial intermediate peptidase (Oct1, YKL134C) to lower matrix iron concentration, directly and by competition [ 33].


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