Words similar to frameshift
Example sentences for: frameshift
How can you use “frameshift” in a sentence? Here are some example sentences to help you improve your vocabulary:
Whole pseudogenes were found by searching for matches to SWISS-PROT protein sequences in intergenic DNA, and are usually characterized by frameshift mutations or early stop codons that prevent normal transcription or translation [ 18, 19].
The presence of internal stop codons and frameshift mutations was used to classify a sequence as a pseudogene only if the feature could be confirmed in another sequence derived from an independent cDNA or genomic library, or if the original sequence contained three or more such features in any 60-amino-acid stretch.
Two frameshift mutations, a G-to-T transversion in the intron 9 splice donor site, and a G-to-A transition in the intron 5 splice donor site, cause an exon to be skipped resulting in abnormal metabolism of GABA, an important neurotransmitter in the brain.
Some cases of HSP result from mutations in the gene for paraplegin, a nuclear-encoded mitochondrial metalloprotease, including: a 2 bp deletion at position 784, which causes a frameshift that eliminates 60% of the protein; and an adenine insertion at position 2,228 of the paraplegin cDNA, which creates a frameshift resulting in truncation of the last 57 residues of this 795-residue protein [ 37].
This mutation, common among families with hereditary ovarian cancer, is a frameshift mutation occurring at the beginning of the C 3 HC 4 region of exon 2 that essentially interrupts RING domain function [ 19 29 30 ] . The results showed that disruption of the BRCA1 amino-terminal RING domain altered caspase 3 activation and subsequent DFF45 and PARP cleavage, resulting in accelerated STS-induced apoptosis.
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