Words similar to frameshift

Example sentences for: frameshift

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The presence of internal stop codons and frameshift mutations was used to classify a sequence as a pseudogene only if the feature could be confirmed in another sequence derived from an independent cDNA or genomic library, or if the original sequence contained three or more such features in any 60-amino-acid stretch.
Probable pseudogenes were identified on the basis of the presence of a poly(A) tail at the 3' end of corresponding genomic sequences, the presence of internal stop codons or the presence of frameshift mutations within the catalytic domain.
As seen in Figure 9, both frameshift mutations lead to elimination of a highly conserved motif (NCVpRFaDT) near the carboxyl terminus of the peptide - a region that must be critical to proper function or folding.
Two frameshift mutations, a G-to-T transversion in the intron 9 splice donor site, and a G-to-A transition in the intron 5 splice donor site, cause an exon to be skipped resulting in abnormal metabolism of GABA, an important neurotransmitter in the brain.
Both mutant mRNAs encode internally deleted proteins without a frameshift.