Example sentences for: frame-shift

How can you use “frame-shift” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Primers for the frame-shift mutant, fs-α 1S , were originally designed to delete the 20-mer Thr671-Leu690 in the cytosolic loop between repeats II and III of α 1S and to generate a full-length α 1S carrying this internal deletion.

  • In the present report, we characterized a frame-shift mutant of α 1S that expresses two complementary fragments of α 1S . Complementation between the two α 1S fragments produced recovery of EC coupling in dysgenic muscle cells lacking α 1S . The results suggest the EC coupling voltage sensor of skeletal muscle is modular in function and can be assembled from separate hemi-Ca 2+channel fragments.

  • The present studies show EC coupling recovery by a frame-shift mutant of α 1S due to protein-protein complementation of the N-terminal and C-terminal halves of α 1S . The N-terminal half houses repeats I and II with the adjoining cytosolic loop and the C-terminal half houses most of the II-III loop, along with repeats III and IV with the adjoining loop.

  • Expression of a frame-shift mutation of α 1Sin dysgenic myotubes

  • This frame-shift mutation was re-ligated into an otherwise full-length α 1S , subcloned into the mammalian expression vector pSG5, and transfected into dysgenic (α 1S null) myotubes.


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