Words similar to foxc

Example sentences for: foxc

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These genes include PITX2, PITX3, PAX6, FOXC1 (previously known as FKHL7 and FREAC3), Foxc2 and FOXE3 [ 4 5 6 7 8 9 ] . Activity levels for these transcription factors normally associated with diploid gene dosage are important for normal ocular development, with heterozygosity for null mutations in most of these genes causing anterior segment dysgenesis.
The phenotypic variability both between and within the eyes of genetically uniform mice with Bmp4 or Foxc gene mutations indicates that stochastic developmental events are important in determining the phenotypic outcome.
For FOXC1 and PAX6, both haploinsufficiency and increased gene dosage due to gene duplication result in abnormal ocular development [ 10 11 12 13 ] . Similarly, a mutation in PITX2 that results in increased transcriptional transactivation causes ASD [ 14 ] .
For general anterior segment development, this is supported by the observations that genetic deficiency of transcription factors such as PAX6, PITX2, FOXC1 [ 44, 45], and LMX1B that are expressed in the periocular mesenchyme results in anterior segment dysgenesis in both humans and mice [ 46, 47, 48, 49, 50, 51, 52, 53, 54].
The nature and variability of anterior segment phenotypes of Bmp4 +/-heterozygotes resemble those we reported in mice with dominant mutations in the forkhead box genes Foxc1 and Foxc2 [ 42 ] . However, the Bmp4 haploinsufficient phenotype is typically more severe.