Example sentences for: four-fold

How can you use “four-fold” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The first part of P dips into the transmembrane region as an α-helix and its latter portion returns to the surface in a relatively extended conformation that lies near the four-fold axis of the pore.

  • [ 20] found that among a cohort of 100 Swedish patients who had undergone hip arthroplasty, female patients who were heterozygous for the factor V Leiden mutation had a four-fold increased risk of thrombosis.

  • Plasmid DNA was diluted four-fold in water and 2 μl of the diluted sample was sequenced in 96-well format using the Dye Terminator Cycle Sequencing Kit (Beckman Coulter, Inc.).

  • These observations can not be accounted for by differences in exposure to ACV and PCV since oral administration of VCV and FCV results in almost identical blood concentration-time curves for ACV and PCV [ 11 ] . A more probable explanation is that ACV is approximately four-fold more potent than PCV in murine cells [ 21 ] .

  • Analysis of the crystal structure of GlpF suggests that potential ion binding sites may be located in the central pore, at the four-fold axis of symmetry in the tetrameric association of subunits that form the channel [ 15 ] . Interestingly, this arrangement of a tetramer of subunits to form a central ion pore is a hallmark of the family of voltage-gated ion channels [ 23 ] , which rely on a tetrameric organization to create a central pore for ions that is lined by sequences contributed from all four subunits.


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