Example sentences for: forskolin

How can you use “forskolin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • On the other hand, it has been previously demonstrated that direct activation of adenylate cyclase by Forskolin or cholera toxin, inhibition of cAMP-specific phosphodiesterase, and treatment with a cell permeable cAMP analog, induces a rise in intracellular cAMP [ 22 23 24 25 26 ] . Since cAMP is known to modulate the expression of CD8 in mice [ 27 ] , we sought to determine whether cAMP-dependent protein kinase (PKA)-mediated signaling plays a role in modulating the mRNA levels of CD3, CD4, and CD8 in ex vivo examined human thymocytes.

  • Inhibition of Forskolin stimulated cyclic AMP (cAMP) production by exposure to increasing concentrations of agonists were evaluated in intact cells.

  • The efficacy of each ligand was defined as percent inhibition of forskolin stimulated cAMP production compared to no ligand levels (0% inhibition, 100% cAMP production).

  • The inhibitory action of 4-AP on progesterone production was investigated further using not only primary cultures, but also the spontaneously established granulosa cell line, PGC-2 [ 19 ] . Although PGC-2 lack FSH receptors, these cells can serve as a useful in vitro model for GC function, because they produce cAMP in response to forskolin and synthesize progesterone and estradiol when supplied with appropriate substrates.

  • Stock solutions of forskolin (10 mM) and 3-isobutyl-1-methylxanthine (IBMX, 80 mM) were in DMSO.


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