Words similar to forkhead
Example sentences for: forkhead
How can you use “forkhead” in a sentence? Here are some example sentences to help you improve your vocabulary:
PIP3: Phosphatidyl-3,4,5-triphosphate; DMEM: Dulbecco's Modified Eagle's Medium; PI-3Kinase: phosphatidylinositol-3-kinase; MAPK: mitogen-activated protein kinase; IGF: insulin-like growth factor; PTEN: phosphatase and tensin homolog deleted from chromosome 10; SOS: son-of-sevenless ras exchange factor; ASK: apoptosis stimulating kinase; FKHR: forkhead related protein; cFLIP: cellular FLICE interacting protein; BSA: bovine serum albumin; TBS: tris buffered saline; PVDF: polyvinylidene difluoride
408182 [http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=408182; forkhead box D1 (Hs.
Akt directly phosphorylates and inactivates the pro-apoptotic proteins ASK1, BAD, caspase 9 [ 21 22 23 24 ] . Akt also induces the expression of the anti-apoptotic Bcl-2 and c-FLIP proteins, and suppresses the cell cycle inhibitor p27 KIP [ 25 26 27 28 ] . This later effect is via the phosphorylation and inactivation of the forkhead family of transcription factors AFX, FKHR and FKHR-L1.
The nature and variability of anterior segment phenotypes of Bmp4 +/-heterozygotes resemble those we reported in mice with dominant mutations in the forkhead box genes Foxc1 and Foxc2 [ 42 ] . However, the Bmp4 haploinsufficient phenotype is typically more severe.
However, recent reports indicate that transcription of the p27 Kip1gene can be activated by neuronal differentiation [ 12 ] , treatment with vitamin D3 [ 13 14 ] , interferon and cytokines [ 15 16 17 ] , and exposure to hypoxic conditions [ 18 ] or xenobiotics [ 19 ] . Transcription of the p27 Kip1gene can be negatively regulated by growth factors [ 20 ] and by c-Myc [ 21 ] . Some of the growth factor and cytokine effects on p27 Kip1transcription may be mediated by the forkhead family of transcription factors that appear to be regulated downstream of the phosphatidylinositol 3-kinase signaling pathway [ 22 23 24 25 ] . The use of alternative promoters leading to multiple transcription start sites, as reported here, suggests an additional type of transcriptional control.
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