Words similar to folds
Example sentences for: folds
How can you use “folds” in a sentence? Here are some example sentences to help you improve your vocabulary:
Organic phosphate compounds are the central metabolites of all biological systems [ 1 2 ] . Some are the basic building blocks of nucleic acids, some like ATP and GTP, are additionally, cellular energy stores, others like cAMP or cGMP are messengers in signal transduction, and, yet others, such as FAD, NAD, thiamine phosphates and pyridoxal phosphate are cofactors for a range of enzymes [ 1 2 ] . Protein domains belonging to a relatively small set of structural folds are known to bind or catalyze reactions that utilize these organic phosphate compounds (see SCOP database: http://scop.mrc-lmb.cam.ac.uk/scop/) [ 3 4 ] . Several of these folds trace back to some of the earliest phases of the evolution of the protein world, and participate in a wide range of disparate biological functions in extant proteins [ 4 5 ] . Some folds, such as the P-loop fold, the Rossmann fold and the Hsp70-like fold, have been well studied, and comprise mainly of dedicated nucleotide binding or hydrolyzing proteins [ 6 7 8 9 ] . Others, such as the palm-domain, which is found in adenylyl cyclases and various nucleic acid polymerases, belong to more generalized protein folds that contain representatives with diverse biochemical activities [ 4 10 11 ] . Current availability of extensive genome sequence data, allows one to identify less numerous, nevertheless biological important organic phosphate-binding domains that may have previous eluded detection.
Further instances cited in genomic biology include the occurrence of protein families or folds [ 5, 6, 7, 8, 9], the connectivity within metabolic pathways [ 10] and the number of intra- and intermolecular interactions made by proteins [ 11, 12, 13].
Nevertheless, the occurrences of families, superfamilies, and folds in the worm approximate to a power-law behavior quite well (Figure 1a).
The common structures satisfy the shape-covering theorem, which states that within any sphere of a certain radius r , at least one sequence can be found that folds into a given common structure.
The behavior also applies to the number of distinct protein-protein interactions made by different folds ( b = 1.2) and the number of transcripts for each protein family in yeast in a given cellular state ( b = 1.6).
Loading...