Words similar to flavopiridol

Example sentences for: flavopiridol

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This understanding of mRNA turnover on a genomic scale provides fresh insights into the effectiveness of flavopiridol as an anti-cancer agent.
, less than 100 nM) can selectively suppress HIV-1 transcript elongation without altering cellular transcripts in cell types of various lineages, including podocytes [ 7 29 30 ] . Cyclin D 1 transcript levels were followed before, during, and after treatment of confluent wild-type or HIV-1 infected podocytes with 50 nM flavopiridol, a dose that suppresses HIV-1 transcription by 70% [ 7 ] . Analysis of HIV-1, cyclin D 1 , and glyceraldehyde-3-phosphate dehydrogenase (G3PDH) transcript levels in podocytes treated with flavopiridol for 2 days, followed by drug washout for 1 day, showed that cyclin D 1 expression paralleled HIV-1 expression in infected podocytes before, during and after suppression of HIV-1 genes (Figure 4).
Flavopiridol is a member of the growing family of CDK inhibitors that have varying activities against the multiple CDK family members.
In accord with these results, flavopiridol treatment was recently shown to downregulate two of these anti-apoptotic proteins, MCL1 and Bag-1, and induce apoptosis in B-CLL cells treated with flavopiridol [ 29].
PBMCs were first activated at 5 × 10 6cells/ml with PI for 3 h before flavopiridol treatment.