Words similar to flavopiridol
Example sentences for: flavopiridol
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The magnitude of the flavopiridol effect on gene expression was related to the dose of the drug used (Figure 1a).
The following additional data files containing the primary data for the figures are included with this article: Figure 1a, flavopiridol titration ( Excel csv file); Figure 1c, Cdk inhibitors ( Excel csv file); Figure 2a, flavopiridol, actinomycin D and DRB ( Excel csv file); Figure 3, half-lives of well-measured genes ( Excel csv file); Figure 4a, proliferation genes ( Excel csv file); Figure 4b, anti-apoptotic genes ( Excel csv file); Figure 4d, induced genes in OCI -Ly3 cells ( Excel csv file); Figure 5c, highly induced genes in PBMC ( Excel csv file); Figure 5d, highly induced chemokines, cytokines and their receptors ( Excel csv file).
In support of this notion, we show here that cyclin D 1 expression parallels HIV-1 expression before, during, and after suppression of HIV-1 transcription with flavopiridol, and recently, we showed that longer periods of treatment with flavopiridol ameliorate the phenotypic abnormalities of infected podocytes [ 7 ] .
As shown in Figure 1c, the gene expression changes caused by roscovitine and 9-nitropaullone were different from those of flavopiridol, and only flavopiridol globally reduced mRNA levels.
To investigate the effect of flavopiridol treatment on activated B-like DLBCL, we used cell line OCI-Ly3 as our model of activated B-like DLBCL as its gene-expression profile closely resembles the profiles of lymphoma biopsy samples from patients with this type of DLBCL [ 1].