Example sentences for: fkbp
How can you use “fkbp” in a sentence? Here are some example sentences to help you improve your vocabulary:
p60/Hop, p23, hsp40, FKBP52, and FKBP51) have been implicated in the assembly/stabilization of the GR-hsp90-hsp70-complex in a form that has high affinity for agonist [for review, see Ref.
FK506-binding protein 5/FKBP51 is a co-chaperone protein that has peptidylprolyl isomerase activity and interacts with the progesterone receptor [ 25].
One of these, FK506-binding protein 5/FKBP51, a recently described androgen target [ 24], was the most highly induced gene (more than 20-fold) we observed in our experiments.
The long-term treatment of patients with either CsA or TAC results in side effects such as nephrotoxicity, hypertension, and gingival hyperplasia [ 1 2 ] . Sirolimus (SRL) a new immunosuppressive agent is structurally similar to TAC binds to same binding protein FKBP, but its mechanism of action is different [ 3 ] . Both clinical and experimental studies demonstrated that SRL when used either with CsA or alone is associated with side effects such as hyperlipidemia, thrombocytopenia and nephrotoxicity [ 4 5 6 7 ] . Since SRL and TAC have affinity for the same binding site, it was thought to be ineffective when used together.
A number of studies have demonstrated that long treatment of both CsA and TAC is associated many side effects such as nephrotoxicity, hypertension, and gingival hyperplasia [ 1 2 ] . Rapamycin clinically termed, as Sirolimus (SRL) is a new immunosuppressive agent, which is structurally similar to TAC, binds to same binding protein FKBP, but has different mechanism of action [ 3 ] . Both clinical and experimental studies demonstrated that SRL when used either with CsA or alone is associated with side effects like hyperlipidemia, thrombocytopenia and nephrotoxicity [ 4 5 6 7 ] . SRL and TAC compete for the same binding site and hence it was thought they could not be used concomitantly.
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