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Example sentences for: fission
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Meiotically induced, Spo11 (Rec12)-dependent double-strand DNA (dsDNA) breaks have been demonstrated in budding yeast and fission yeast [ 12 13 14 15 ] . Spo11 almost certainly catalyzes these breaks, as it shares high homology with the A subunit of Topoisomerase VI of Sulfolobus shibatae [ 16 17 ] and it becomes linked by a phosphotyrosine linkage to the 5' end of the cleaved DNA [ 18 19 20 21 ] . Spo11 homologs have been identified in a wide range of eukaryotes, and available evidence suggests that initiation of meiotic recombination via Spo11-dependent dsDNA break formation is conserved [ 22 23 24 25 ] . Our results with the fission yeast S. pombe fully support this view (see results and discussion).
Pcu1p, another fission yeast cullin also accumulated in the neddylated form in all csn mutants [ 10] (Fig.
Proteasomes translocated to meiotic spindles of rat oocytes and MG-132 induced-inhibition of proteasomal activity resulted in partial segregation of chromosomes during meiosis I [ 42 ] . Moreover, defective proteasomal activity in fission yeast impaired chromosome segregation [ 38 ] .
Although recombinant Pct1 and Pce1 enzymes have been purified and characterized biochemically, and shown to function in cap formation when expressed in S. cerevisiae [ 12 20 21 ] , there have been no antecedent genetic studies of the essentiality of Pct1 or Pce1 in fission yeast.
As described previously in this paper and elsewhere [ 38 ] , the biology of fission yeast facilitates the identification of MII segregation defects that are difficult to detect in other organisms that terminate meiotic progression or produce inviable meiotic products as a consequence of defects in meiotic chromosome dynamics.
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