Words similar to fission
Example sentences for: fission
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Several lines of evidence suggest that the SCF pathway is also conserved in the fission yeast Schizosaccharomyces pombe . Pcu1p, a Cdc53p/CUL1-related protein, was shown to associate with two different F-box/WD repeat proteins, Pop1p and Pop2p, when overexpressed [ 18 ] . In addition, genetic studies demonstrated that both of these F-box proteins are simultaneously required for efficient destruction of Rum1p and the replication initiator Cdc18p [ 18 19 20 ] . Rum1p is a Sic1p-analogous CDK inhibitor, which accumulates in G1, but is degraded as cells enter S phase [ 21 22 ] . Failure to degrade Rum1p is the major phenotypic defect of pop1 and pop2 deletion strains, which leads to disturbance of normal cell cycle progression, resulting in polyploidy [ 18 19 20 23 ] . Based on the genetic data and the biochemical observation that Pop1p and Pop2p interact when overexpressed, a putative SCF Pop1p-Pop2pcomplex was proposed, which would contain the heterooligomerizing F-box proteins Pop1p and Pop2p bound to SCF core components [ 18 20 ] .
For instance, an asexual strain of Dugesia (S) mediterranea exhibits morphological heteromorphosis in the third pair of chromosomes [ 4 ] . Worms belonging to different asexual strains of Dugesia japonica and Girardia (formerly Dugesia ) tigrina are triploid or mixoploid, while sexual strains are diploid [ 5 6 ] . Asexual strains are represented by independent populations that propagate only by fission.
In addition, fission yeast mutants deficient in the enzymes that attach Ned8p, or in the ned8 gene itself, are inviable [ 5].
In the fission yeast Schizosaccharomyces pombe, the execution of Start requires the activity of the Cdc2 protein kinase and the Cdc10/Sct1 transcription complex.
Pcu1p, another fission yeast cullin also accumulated in the neddylated form in all csn mutants [ 10] (Fig.
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