Words similar to filament
Example sentences for: filament
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In previous work, when this method was applied to MHCK-A-expressing cell lines the elevated expression of MHCK-A resulted in myosin II hyperphosphorylation and myosin II filament disassembly, and corresponding loss of ability of cells to grow in suspension [ 24 ] . We observed the same effect in the current studies in attempting to force high expression of FLAG-MHCK-C.
In iron starved conditions, bacterial growth rate is reduced and morphological changes such as filament formation takes place which suggests an inhibition of DNA synthesis or cell division [ 21 22 ] . Besides these the concentration of the proteins whose synthesis is regulated by iron are also observed to get changed [ 23 ] .
In the lens, alpha-crystallin also associates with type III intermediate filament proteins and the beaded filament proteins CP49 and CP115, and correct beaded filament assembly has been shown depend on the presence of alpha-crystallin [ 16 ] . Beaded filament mRNA levels are greatly increased in differentiating lens epithelium and have been suggested as a pan-specific marker for lens fiber development [ 17 ] . Alpha-crystallin has also been shown to interact directly with DNA [ 18 ] . In transfected CHO cells, alphaB has also been shown to ectopically localize to interphase nuclei, suggesting a role for this protein in the nucleus [ 19 ] . A nuclear role for alphaB in the lens was supported by the findings that a subset of lens epithelial cells derived from alphaB knockout mice demonstrated hyperproliferation and genomic instability [ 20 ] . In addition, the administration of exogenous alpha-crystallin to primary bovine lens epithelial cell cultures resulted in the formation of lentoid bodies, consistent with a role for these proteins in lens differentiation [ 21 ] . These findings indicate that alpha-crystallin may have a multitude of in vivo functions.
In the lens, alpha-crystallin also forms a complex with type III intermediate filament proteins and the lens-specific beaded filament proteins CP49 and CP115, which may be critical for proper filament assembly [ 16 ] . Beaded filament mRNA levels increase greatly in differentiating lens epithelial cells, and have been suggested as a pan-specific marker for lens fiber cells [ 17 ] . It is therefore possible that increased synthesis of alpha-crystallin in epithelial cells early in the differentiation process may have profound effects upon the cytoskeleton, which in turn may profoundly affect cell shape and migration.
The astrocyte lineage of the LTR lines has been published [ 6 13 ] . The astrocyte lineage of the tkT lines was confirmed by the presence of the astrocyte-specific intermediate filament protein, GFAP [ 14 ] (Figure 1).
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