Words similar to filament
Example sentences for: filament
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Both VASP and WAVE function in controlling actin dynamics at the leading edge - VASP is thought to promote filament elongation, and WAVE, actin nucleation [ 25 26 ] . Both VASP and WAVE1 were de-localized from the leading edge after 1 min of BDM treatment [Figure 4].
Each filament was applied perpendicularly to the plantar surface of the ligated paw of rats kept in suspended wire-mesh cages.
We suggest that differential localization of MHCKs occurs in D. discoideum cells for the purpose of regulating myosin II filament assembly levels in the context of specific cellular contractile events such as lamellipodium extension and cytokinetic furrowing.
No incorporation was detected on autoradiographs at the mobility of myosin light chains, supporting the model that MHCK-C, like MHCK-A, modulates filament assembly and not myosin motor activity (data not shown).
One process inhibited by BDM is the centripetal flow of actin from the leading edge into the cell body, known as retrograde flow [ 11 12 ] . Retrograde flow is thought to be driven by a "push-pull" mechanism of polymerization of actin at the leading edge of the cell and contractile activity of myosin motor proteins [ 13 14 ] . Formation of new actin filaments is predominantly mediated by the nucleation activity of the Arp2/3 complex [ 15 ] . Members of the WASP/WAVE family of proteins, among others, stimulate and regulate the Arp2/3 complex for spatial and temporal control of filament nucleation [ 15 ] . Localization of these proteins to the leading edge, though not completely understood, is probably mediated through their interactions with the actin cytoskeleton itself and membrane-associated binding partners [ 15 16 ] .
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