Words similar to fibrogenic

Example sentences for: fibrogenic

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Some of the fibroblasts differentiate into myofibroblasts, which contract to close the wound [ 4 14 15 ] . Myofibroblasts are fibrogenic, showing elevated expression of interstitial collagens, laminin, FN and TN, and inhibitors of matrix metalloproteinases such as TIMP-1 [ 15 16 17 18 19 ] . Because cCAF is expressed highly in the granulation tissue of wounds in areas where ECM is abundant [ 3 6 11 ] , and it stimulates fibroblasts to differentiate into myofibroblasts [ 4 ] , we investigated whether this chemokine stimulates the production of the four major ECM molecules mentioned above, interstitial Colls I and III, TN and cellular FN.
This is an ADAM10-homolog known to be a tumor necrosis factor-α (TNFα) convertase [ 21 ] , TNFα produced by Kupffer cells in the liver stimulates production of TNFα, a mitogen for hepatocytes helping to generate new cells needed to rebuild damaged areas of the liver [ 22 ] . Kupffer cells have a significant role as mediators of acute inflammation after CCl 4 treatment; however, they also produce factors that can cause secondary injury in the liver through fibrogenic responses.