Words similar to fibrillin-

Example sentences for: fibrillin-

How can you use “fibrillin-” in a sentence? Here are some example sentences to help you improve your vocabulary:

The deposition of newly synthesized fibrillin into the matrix was greatly reduced (13 % of normal), however, suggesting that the internally deleted mutant fibrillin-1 molecules are secreted and exert a dominant-negative effect on extracellular microfibril assembly.
Deletion of the EGF-like domains encoded by exons 60-62 in the C-terminal domain of fibrillin-1 results in a much less severe phenotype than deletion of three EGF-like domains in the second longest stretch of EGF-like domains (between exons 43-49).
Deletion of one EGF-like domain due to exon skipping, especially in the region between exon 24 and 32, usually causes severe neonatal-onset MFS [ 8 24 25 ] . Similar deletions in other regions of fibrillin-1 may also result in early onset of cardiovascular symptoms [ 8 ] . Patient 1, described here, had a genomic deletion of exons 42 and 43 that results in an in-frame deletion of part of the 5th LTBP-like domain and the adjacent downstream cbEGF-like domain.
The levels of fibrillin-1 production and deposition in the extracellular matrix were expressed as the percentage of values obtained for simultaneously studied normal control fibroblast cultures.
Thus, it appears that deletion of three contiguous EGF-like domains can have different effects depending on their location within the fibrillin-1 molecule.