Words similar to fenfluramine
Example sentences for: fenfluramine
How can you use “fenfluramine” in a sentence? Here are some example sentences to help you improve your vocabulary:
We first sought to identify all published studies with echocardiographic assessment of cardiac valve regurgitation in persons exposed to fenfluramine or dexfenfluramine and in suitable controls.
Some recent reviews conclude that the risks associated with fenfluramine and dexfenfluramine are similar, real but modest for aortic valve disease, and barely detectable for mitral valve disease; phentermine appears not to be associated with increased risk [ 17 18 19 20 ] . Nevertheless, interpretation of the results of these studies has been so varied that some authors have even questioned any causal relationship for fenfluramine exposure [ 21 ] . However, analyses to date have not formally considered major biases that would act to deflate the actual risk associated with fenfluramine use.
This was the first case against American Home Products (AHP) for making fenfluramine, the dangerous half of the combination, which "cause[s] heart valve damage in some patients and lung problems in others."
Since the initial report by Connolly, et al [ 1 ] of valvulopathy in women taking the combination of fenfluramine and phentermine (fen-phen), controversy has surrounded the issue of associated risk.
Indeed, the most recently published study (which did not suffer from measurement bias) showed a high prevalence (30%) of AR in persons taking fenfluramine or dexfenfluramine at the time of the echocardiogram, similar to the older prevalence studies [ 15 ] . Regarding the potential reversibility of valve dysfunction, great caution must be exercised in assuming any substantial reversal of valvular plaques, as recent pathological studies suggest a progressive nature to these lesions [ 33 ] . Furthermore, limited, early apparent echocardiographic improvement of acute rheumatic carditis has also been recently demonstrated [ 34 ] . The early improvement seen in this setting certainly does not preclude later progression of rheumatic valvular heart disease.
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