Example sentences for: fenfluramine

How can you use “fenfluramine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This week, the FDA reported 58 new cases of abnormal heart valves in patients on fen-phen, and the Journal of the American Medical Association reported animal evidence linking both dexfenfluramine and fenfluramine to toxic brain effects.

  • Data provided in this study can be used to estimate the relative contribution of exposure to fenfluramines to overall incidence of echocardiographically defined, FDA-positive AR and MR. Given that approximately 2.5% of the population of the United States had used anorexic prescription drugs (mostly fenfluramine and dexfenfluramine) between 1996 and 1998 [ 30 ] , approximately 32% and 11% of all FDA-positive AR and MR respectively could be attributed to fenfluramine or dexfenfluramine use.

  • Indeed, the most recently published study (which did not suffer from measurement bias) showed a high prevalence (30%) of AR in persons taking fenfluramine or dexfenfluramine at the time of the echocardiogram, similar to the older prevalence studies [ 15 ] . Regarding the potential reversibility of valve dysfunction, great caution must be exercised in assuming any substantial reversal of valvular plaques, as recent pathological studies suggest a progressive nature to these lesions [ 33 ] . Furthermore, limited, early apparent echocardiographic improvement of acute rheumatic carditis has also been recently demonstrated [ 34 ] . The early improvement seen in this setting certainly does not preclude later progression of rheumatic valvular heart disease.

  • Initial reports of remarkably high prevalence of aortic and mitral regurgitation (AR and MR) as assessed by echocardiography in five separate populations [ 2 ] were subsequently supported by most [ 3 4 5 ] but not all investigators [ 6 ] . These uncontrolled reports were soon followed by a series of studies in which prevalence of echocardiographically-defined AR and MR were assessed in persons who had taken fenfluramine, dexfenfluramine, phentermine, or combinations of these medications and compared to unexposed, matched control populations [ 7 8 9 10 11 12 13 14 15 ] . The most recent of these studies found 30% of persons currently taking fenfluramine or dexfenfluramine had mild or greater AR or moderate or greater MR, similar to the very high prevalence reported in older studies [ 15 ] . The only prospective study found a significant, exposure-related increase in the risk of clinically diagnosed valve disease among users of fenfluramine and dexfenfluramine, but not phentermine [ 16 ] .

  • Dr. Hopkins and Dr. Polukoff have been retained as consultants for plaintiff attorneys representing persons who have taken fenfluramine and dexfenfluramine.


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