Words similar to fenfluramine
Example sentences for: fenfluramine
How can you use “fenfluramine” in a sentence? Here are some example sentences to help you improve your vocabulary:
The search for studies included examination of prior meta-analyses and reviews, MEDLINE search (using the terms fenfluramine or dexfenfluramine, diet drugs, echocardiogram or echocardiographic, and valvular heart disease), and review of references of identified articles.
Initial reports of remarkably high prevalence of aortic and mitral regurgitation (AR and MR) as assessed by echocardiography in five separate populations [ 2 ] were subsequently supported by most [ 3 4 5 ] but not all investigators [ 6 ] . These uncontrolled reports were soon followed by a series of studies in which prevalence of echocardiographically-defined AR and MR were assessed in persons who had taken fenfluramine, dexfenfluramine, phentermine, or combinations of these medications and compared to unexposed, matched control populations [ 7 8 9 10 11 12 13 14 15 ] . The most recent of these studies found 30% of persons currently taking fenfluramine or dexfenfluramine had mild or greater AR or moderate or greater MR, similar to the very high prevalence reported in older studies [ 15 ] . The only prospective study found a significant, exposure-related increase in the risk of clinically diagnosed valve disease among users of fenfluramine and dexfenfluramine, but not phentermine [ 16 ] .
Dexfenfluramine (tradenamed Redux), a cousin of fenfluramine, was just released.
There were differences in study design and methods (though most were quite similar), fenfluramine or dexfenfluramine doses (though in most studies, doses were similar), additional drugs used, patient characteristics, interval between cessation of therapy and echocardiography, and completeness of follow-up.
In 1995, a combination of two drugs, fenfluramine and phentermine--fen-phen--was shown to suppress appetite enough to help the severely obese lose an average of 24 pounds after two years.
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