Words similar to far-reaching

Example sentences for: far-reaching

How can you use “far-reaching” in a sentence? Here are some example sentences to help you improve your vocabulary:

The Washington Post leads with "the most extensive and far-reaching reforms" ever proposed for the UN--which means, it turns out, neither staff nor budget cuts.
At the same time, though in a far less formal way, consensus building also began in June for yet another far-reaching proposal for the courts' consideration, one with a distinctive pro bono element - the so-called Public Service Alternative Bar Examination.
The crystal structures of the metallo-β-lactamases reveal a complex and far-reaching hydrogen-bonding network around the metal binding sites, and disruption of this network is predicted to affect metal binding [ 37 42 44 45 48 49 62 63 ] . With all of the mutants described here except the S224K mutant, each mutant binds wild-type or near-wild-type levels of Zn(II) after purification.
Dowd declines to answer, but does propose a far-reaching "gross-out theory" in which politics and media, driven by America's gradual desensitization and need for stimulation, have fallen to new depths of tastelessness.
Since adopting low-dose challenge approaches has far-reaching consequences for the design of efficacy trials of vaccines or preventive treatment in animal models, we would like to discuss how some important aspects of trial design, such as transient infections, the challenge schedule, the route of infection, and the phenotype and dose of the challenge strain, should be dealt with and could be optimized.