Words similar to far-reaching

Example sentences for: far-reaching

How can you use “far-reaching” in a sentence? Here are some example sentences to help you improve your vocabulary:

The crystal structures of the metallo-β-lactamases reveal a complex and far-reaching hydrogen-bonding network around the metal binding sites, and disruption of this network is predicted to affect metal binding [ 37 42 44 45 48 49 62 63 ] . With all of the mutants described here except the S224K mutant, each mutant binds wild-type or near-wild-type levels of Zn(II) after purification.
President Bush has a strong track record on enacting far-reaching clean air initiatives.
In its original form, the article accused Clinton of numerous, far-reaching offenses, including making misleading statements in televised appearances.
An additional example of the far-reaching consequences of host tryptophan catabolism is illustrated by the potential for persistent immune activation to disrupt the balance between serotonin and kynurenine production from tryptophan, thus linking the immunological network and neuropsychiatric consequences of serotonin imbalance [ 24].
In Australia, in remarks titled Why Legal Services Has to Change, Youells said, "over the last several years, the legal services community in the United States has pursued a fundamental review of our delivery system-the most far-reaching and challenging we have ever undertaken.