Words similar to fap
Example sentences for: fap
How can you use “fap” in a sentence? Here are some example sentences to help you improve your vocabulary:
Polyps (multiple) are generally localized to the small intestine in Min /+ mice, opposed to the colons of FAP suffers [ 27 ] . In Min /+ mice adenoma formation is thought to occur within the first few weeks of life, with a full compliment of adenomas being attained by approximately 9 weeks of age (60-67 days of age) [ 6 28 ] . Following this time, adenoma multiplicity is thought not to change, however, adenoma size may still increase [ 6 28 ] . Min /+ mice are also normally found to develop anaemia by 60 days of age and possess a shortened life span of roughly 120 days (17 weeks) [ 29 ] .
Sulindac has been shown to be efficacious both in rodent models of FAP and in human FAP patients.
The Min /+ model has received great favour because it contains a mutation in the Apc gene, which is homologous to the human adenomatous polyposis coli (APC) gene [ 23 ] . Defects in the APC tumour suppressor gene are thought to play a role in greater than 70% of all colorectal cancers and is responsible for inherited syndromes of polyposis (FAP and Gardner's) [ 24 25 ] . Furthermore, in humans the majority of colorectal cancers arise from adenomatous polyps [ 26 ] .
To date no studies or case reports have examined the use of aspirin in the treatment of FAP, although various clinical trials are under way [ 33 ] . In accordance with the above data, studies conducted in animals have always employed a prevention strategy as well [ 4 7 9 ] . To our knowledge, this is the first study to examine the therapeutic potential of aspirin in a rodent model of colon carcinogenesis, in particular, the Min /+ murine model of polyposis.
Polyposis in the Min /+ mouse differs slightly from the human condition of FAP.
Loading...