Words similar to fap
Example sentences for: fap
How can you use “fap” in a sentence? Here are some example sentences to help you improve your vocabulary:
Polyps (multiple) are generally localized to the small intestine in Min /+ mice, opposed to the colons of FAP suffers [ 27 ] . In Min /+ mice adenoma formation is thought to occur within the first few weeks of life, with a full compliment of adenomas being attained by approximately 9 weeks of age (60-67 days of age) [ 6 28 ] . Following this time, adenoma multiplicity is thought not to change, however, adenoma size may still increase [ 6 28 ] . Min /+ mice are also normally found to develop anaemia by 60 days of age and possess a shortened life span of roughly 120 days (17 weeks) [ 29 ] .
Polyposis in the Min /+ mouse differs slightly from the human condition of FAP.
To date no studies or case reports have examined the use of aspirin in the treatment of FAP, although various clinical trials are under way [ 33 ] . In accordance with the above data, studies conducted in animals have always employed a prevention strategy as well [ 4 7 9 ] . To our knowledge, this is the first study to examine the therapeutic potential of aspirin in a rodent model of colon carcinogenesis, in particular, the Min /+ murine model of polyposis.
Sulindac has been shown to be efficacious both in rodent models of FAP and in human FAP patients.
The Min /+ model has received great favour because it contains a mutation in the Apc gene, which is homologous to the human adenomatous polyposis coli (APC) gene [ 23 ] . Defects in the APC tumour suppressor gene are thought to play a role in greater than 70% of all colorectal cancers and is responsible for inherited syndromes of polyposis (FAP and Gardner's) [ 24 25 ] . Furthermore, in humans the majority of colorectal cancers arise from adenomatous polyps [ 26 ] .
Loading...