Words similar to factor-induced
Example sentences for: factor-induced
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In addition, IL-4 inhibits growth factor-induced RA synoviocyte proliferation, and expression of prostaglandin E and matrix metalloproteinase-3 in RA synovial fibroblast [ 14, 15, 16], and reduces bone resorption.
Finally, since the use of CEP cells would allow easy ex vivo gene transfer, combining growth factor-induced therapeutic angiogenesis with gene therapy delivered via CEP should also be a promising approach.
For example, growth factor-induced localization of actin mRNA to the leading edge of fibroblasts is a dynamic, regulated process requiring actomyosin interactions and activation of the RhoGTPase pathway, as well as specific signal sequences in the 3' UTR of the message [ 9 10 11 12 ] . Moreover, disruption of the actin cytoskeleton using pharmacological agents also blocks the association of β-actin mRNA with microfilaments and prevents localization of the transcript to the cell periphery [ 7 13 ] . Mechanical forces exerted on cell surface integrin receptors, which anchor the actin cytoskeleton to the extracellular matrix, also produce changes in the localization of poly(A) mRNA and ribosomal proteins inside the cell [ 14 ] . Importantly, the localization of transcripts can serve as a key regulatory step in gene expression as inhibition of mRNA targeting can significantly impact cell function.