Words similar to extrapyramidal
Example sentences for: extrapyramidal
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Olanzapine therapy is associated with a number of side effects, including somnolence, agitation, nervousness, headaches, dizziness, weight gain, constipation and dry mouth [ 5 ] . Olanzapine, however, does not produce extrapyramidal side effects, postural hypotension or hemotoxicity (a particular problem for patients on clozapine therapy [ 13 ] ). Although urinary retention as a result of olanzapine therapy may be predicted from binding studies due to olanzapine's antimuscarinic activity [ 12 ] only 1 case report of micturition disturbance associated with olanzapine has recently appeared [ 14 ] . On the other hand, several reports of urinary disturbances due to clozapine can be found in the clinical literature [ 3 10 15 ] .
Both have the potential to cause drowsiness and extrapyramidal symptoms, particularly in young women [ 55 ] .
haloperidol) because of their lower incidence of extrapyramidal side effects, their greater efficacy in improving negative symptoms of schizophrenia, and their effectiveness in treating schizophrenic patients not responding to conventional neuroleptics [ 3 ] . However, side effects continue to pose a challenge to effective treatment [ 4 ] . These novel neuroleptics display a complex pharmacological profile with affinities for several receptor systems but are generally characterized by a greater affinity for the 5-HT2A receptor than for the target of the traditional neuroleptics, the D2 receptor [ 4 5 ] .
In addition to the two measures of cognitive functioning, age, gender, time since onset of cognitive problems, use of antipsychotic medication, presence of extrapyramidal symptoms, and living situation were considered as potential predictors.
Far fewer patients overall had extrapyramidal symptoms, however, among those that did, the mean DAD score was lower than for those without symptoms (62% vs 70%, t-test, p-value 0.0037).
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