Example sentences for: extra-cellular

How can you use “extra-cellular” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It is conceivable that a similar mechanism might be used by extra-cellular signals in the thymic epithelium during intrathymic differentiation.

  • The cellular phenotype in culture was characterized by morphology and extra-cellular matrix (ECM) production.

  • In general, they regulate how cells interact with each other and with the extra-cellular matrix.

  • To quantitate the change in cell adhesion in IDO-transfected RAW cells, we performed binding studies to tissue culture plates coated with various extra-cellular matrices, including collagen, laminin, matrigel, and fibronectin.

  • Unfortunately, naive lymphocytes are not susceptible to infection with adenoviruses due to lack of detectable expression of a viral receptor, such as the coxsackie/adenovirus receptor (CAR), which is required for efficient viral attachment [ 8 9 10 ] . The CAR protein contains two extra-cellular immunoglobulin-like (Ig) domains, the first of which appears sufficient for binding to the adenoviral fiber knob protein [ 11 12 ] . Expression of either human or murine CAR in various cell lines has been shown to facilitate gene transfer by recombinant human adenoviruses [ 8 9 10 13 ] . Stable transfection of transformed murine B and T cells lines with human CAR (hCAR) lacking its cytoplasmic domain rendered them susceptible to adenoviral transfection, establishing that lymphoid cells can be permissive hosts for adenoviral transduction and demonstrating that the cytoplasmic domain of CAR is not required for viral entry [ 13 ] . More recently, mice transgenic for full length [ 14 ] or truncated hCAR [ 15 ] have been described in which adenoviral transduction of primary lymphocytes has been demonstrated.


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