Words similar to etoh-induced
Example sentences for: etoh-induced
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In a previous study we observed that the coadministration of SY with EtOH to pregnant dams prevented the EtOH-induced deficits in social recognition observed in the EtOH-exposed offspring [ 20 ] . Social memory in rats is a sexually dimorphic behavior that requires adequate levels of perinatal and neonatal androgen activity.
As an indication of EtOH and SY fetal effects the CC weight measure does not seem to provide much relevant information, whereas the measure of splenium development clearly indicates EtOH-induced disruption.
There is a possible explanation in light of the gender-specific differences observed in callosal size [ 24 ] coupled with the fact that prenatal exposure to EtOH causes feminization of male rats and defeminization of female rats [ 12 25 26 ] . There is a hormonal influence on the developing commissural pathway that could be disrupted by a number of EtOH-induced aberrations in hormone activity, such as the diminished perinatal surge of testosterone observed in EtOH-exposed male fetal rats [ 27 ] . The EtOH-induced attenuation of the testosterone surge eliminated the normal sex difference in rat callosal size.
Without the SY, EtOH-exposed pups clearly displayed EtOH-induced disruption to normal callosal development.
Given that SY has been successful in ameliorating some of the negative consequences of in utero exposure to EtOH (in the rat model), we examined the possibility that SY might prevent EtOH-induced callosal agenesis and the disruption of laterality (as measured by paw preference).
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