Example sentences for: erlotinib

How can you use “erlotinib” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Collectively, these results demonstrate that tumors from all three patients contain EGFR mutations associated with sensitivity to the tyrosine kinase inhibitors gefitinib and erlotinib.

  • Substitution of methionine for threonine at position 790 would be predicted to result in steric hindrance of erlotinib binding to EGFR (Figure 2).

  • To determine whether lung cancers that acquire clinical resistance to either gefitinib or erlotinib display additional mutations in the EGFR kinase domain, we have examined the status of EGFR exons 18 to 24 in tumors from five patients who initially responded but subsequently progressed while on these drugs.

  • Furthermore, the NSCLC cell line H1975 harbors both the L858R and T790M mutations, and is resistant to inhibition by gefitinib or erlotinib, unlike cell lines that express the L858R allele alone.

  • Both of these mutations are associated with sensitivity to the small-molecule kinase inhibitors gefitinib or erlotinib [1,2,3].


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